Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine

doi:10.3389/fmed.2021.815075

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	Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine
	Ling, Jiawei; Chan, Ben Chung-Lap; Tsang, Miranda Sin-Man; Gao, Xun; Leung, Ping Chung; Lam, Christopher Wai-Kei; Hu, Jiang-Miao; Wong, Chun Kwok
	2022
发表期刊	FRONTIERS IN MEDICINE
卷号	8 页码:815075
摘要	Dry eye is currently one of the most common ocular surface disease. It can lead to ocular discomfort and even cause visual impairment, which greatly affects the work and quality of life of patients. With the increasing incidence of dry eye disease (DED) in recent years, the disease is receiving more and more attention, and has become one of the hot research fields in ophthalmology research. Recently, with the in-depth research on the etiology, pathogenesis and treatment of DED, it has been shown that defects in immune regulation is one of the main pathological mechanisms of DED. Since the non-specific and specific immune response of the ocular surface are jointly regulated, a variety of immune cells and inflammatory factors are involved in the development of DED. The conventional treatment of DED is the application of artificial tears for lubricating the ocular surface. However, for moderate-to-severe DED, treatment with anti-inflammatory drugs is necessary. In this review, the immunomodulatory mechanisms of DED and the latest research progress of its related treatments including Chinese medicine will be discussed.
关键词	inflammation signaling pathways immunomodulatory therapy traditional Chinese medicine dry eye disease CHRONIC INFLAMMATORY LESIONS MEIBOMIAN GLAND DYSFUNCTION OCULAR-SURFACE OPHTHALMIC SOLUTION TEAR FILM SJOGRENS-SYNDROME ORAL DOXYCYCLINE MATRIX METALLOPROTEINASES TOPICAL CORTICOSTEROIDS CATARACT-SURGERY
DOI	10.3389/fmed.2021.815075
收录类别	SCI
WOS记录号	WOS:000749877100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75649
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Ling, Jiawei,Chan, Ben Chung-Lap,Tsang, Miranda Sin-Man,et al. Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine[J]. FRONTIERS IN MEDICINE,2022,8:815075.
APA	Ling, Jiawei.,Chan, Ben Chung-Lap.,Tsang, Miranda Sin-Man.,Gao, Xun.,Leung, Ping Chung.,...&Wong, Chun Kwok.(2022).Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine.FRONTIERS IN MEDICINE,8,815075.
MLA	Ling, Jiawei,et al."Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine".FRONTIERS IN MEDICINE 8(2022):815075.

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10.3389_fmed.2021.81（786KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载