Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels

doi:10.3389/fphar.2022.1081697

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	Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels
	Su, Deyuan; Gong, Ye; Li, Songyu; Yang, Jian; Nian, Yin
	2022
发表期刊	FRONTIERS IN PHARMACOLOGY
卷号	13 页码:1081697
摘要	Cyclovirobuxine D (CVB-D), the main active constituent of traditional Chinese medicine Buxus microphylla, was developed as a safe and effective cardiovascular drug in China. B. microphylla has also been used to relieve various pain symptoms for centuries. In this study, we examined and uncovered strong and persistent analgesic effects of cyclovirobuxine D against several mouse models of pain, including carrageenan- and CFA-induced inflammatory pain and paclitaxel-mediated neuropathic hypersensitivity. Cyclovirobuxine D shows comparable analgesic effects by intraplantar or intraperitoneal administration. Cyclovirobuxine D potently inhibits voltage-gated Ca(v)2.2 and Ca(v)3.2 channels but has negligible effects on a diverse group of nociceptive ion channels distributed in primary afferent neurons, including Na(v)1.7, Na(v)1.8, TRPV1, TPRA1, TRPM8, ASIC3, P2X2 and P2X4. Moreover, inhibition of Ca(v)3.2, rather than Ca(v)2.2, plays a dominant role in attenuating the excitability of isolated dorsal root ganglion neurons and pain relieving effects of cyclovirobuxine D. Our work reveals that a currently in-use cardiovascular drug has strong analgesic effects mainly via blockade of Ca(v)3.2 and provides a compelling rationale and foundation for conducting clinical studies to repurpose cyclovirobuxine D in pain management.
关键词	Cyclovirobuxine D Ca(v)3 2 Ca(v)2 Buxus microphylla analgesic effects ROOT GANGLION NEURONS CALCIUM-CHANNELS CELL-PROLIFERATION PACLITAXEL RAT RECEPTOR GENE EXPRESSION APOPTOSIS CURRENTS
DOI	10.3389/fphar.2022.1081697
收录类别	SCI
WOS记录号	WOS:000907595600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75643
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Su, Deyuan,Gong, Ye,Li, Songyu,et al. Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels[J]. FRONTIERS IN PHARMACOLOGY,2022,13:1081697.
APA	Su, Deyuan,Gong, Ye,Li, Songyu,Yang, Jian,&Nian, Yin.(2022).Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels.FRONTIERS IN PHARMACOLOGY,13,1081697.
MLA	Su, Deyuan,et al."Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels".FRONTIERS IN PHARMACOLOGY 13(2022):1081697.

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