Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress

doi:10.1080/10286020.2023.2269370

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	Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress
	Wang,Yin-Yuan; Ni,Jian-Cheng; Zhao,Yue-Qin; Yang,Xu; Niu,Zhen-Peng; Yang,Xing-Zhi; Dong,Xian-Xiang; Zhao,Yu-Han; Hao,Xiao-Jiang; Ding,Xiao
	2023
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1477-2213
摘要	Morinda officinalis is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from M. officinalis were evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed light on the identification of autophagy activators from M. officinalis and provide a basis for developing them in the treatment of oxidative stress-involved diseases.
关键词	Iridoid glycosides Morinda officinalis lysosomal biogenesis TFEB/TFE3 antioxidant activity TRANSCRIPTIONAL CONTROL TFEB PHOSPHORYLATION REVEALS PATHWAY
DOI	10.1080/10286020.2023.2269370
收录类别	SCI
WOS记录号	WOS:001099498200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75611
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Yin-Yuan,Ni,Jian-Cheng,Zhao,Yue-Qin,et al. Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2023.
APA	Wang,Yin-Yuan.,Ni,Jian-Cheng.,Zhao,Yue-Qin.,Yang,Xu.,Niu,Zhen-Peng.,...&Ding,Xiao.(2023).Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.
MLA	Wang,Yin-Yuan,et al."Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2023).

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