Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01

doi:10.1080/14786419.2023.2185889

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	Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01
	Lai,Peng; Wang,Li; Deng,Chenjie; Xu,Yixin; Ma,Xiao-Yan; Cheng,Chun-Ru; Huang,Sheng-Xiong
	2023
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6427
摘要	Two new prenylxanthone derivatives, asperidulins A (1) and B (2), along with a known emodin analogue (3) were isolated from an apple-derived fungus Aspergillus nidulans KIB-HACM-01. Their structures were elucidated by interpretation of HRMS, NMR, and comparisons of specific optical rotation. Asperidulin B (2) exhibited a moderate cytotoxicity against A549 and BEAS-2B with an IC50 values of 13.62 +/- 0.41 and 11.27 +/- 0.52 mu M, and methyl-averantin (3) showed moderate cytotoxicities against all six tested cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480, BEAS-2B) with IC50 values ranging from 8.93 +/- 0.56 to 35.27 +/- 0.25 mu M.
关键词	Prenylxanthones structure elucidation Aspergillus nidulans cytotoxicity
学科领域	Chemistry ; Pharmacology & Pharmacy
DOI	10.1080/14786419.2023.2185889
收录类别	SCI
WOS记录号	WOS:000943867600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75599
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Lai,Peng,Wang,Li,Deng,Chenjie,et al. Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01[J]. NATURAL PRODUCT RESEARCH,2023.
APA	Lai,Peng.,Wang,Li.,Deng,Chenjie.,Xu,Yixin.,Ma,Xiao-Yan.,...&Huang,Sheng-Xiong.(2023).Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01.NATURAL PRODUCT RESEARCH.
MLA	Lai,Peng,et al."Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01".NATURAL PRODUCT RESEARCH (2023).

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