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Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota
Zuo,Zhichuang; He,Zhicheng; Ma,Yan; Xu,Chen; Tao,Xuelin; Ning,Zimo; Gao,Li; Rehemiding,Ailainuer; Gao,Na; Zhao,Jinhua
2023
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN1879-0003
卷号236页码:123935
摘要The slug Vaginulus alte is used as folk medicine in China, but the structure and activities of its galactan com-ponents remain to be clarified. Here, the galactan from V. alte (VAG) was purified. The Mw of VAG was determined as-28.8 kDa. Chemical composition analysis showed that VAG was composed of D-galactose (75 %) and L-galactose (25 %). To elucidate its precise structure, a series of disaccharides and trisaccharides were pu-rified from mild acid hydrolyzed VAG and their structures were characterized by 1D/2D NMR spectroscopy. Based on methylation analysis and structural analysis of oligosaccharides, VAG was elucidated as a highly branched polysaccharide and mainly composed of (1 -> 6)-or (1 -> 3)-linked beta-D-galactose, and distinct (1 -> 2)-linked alpha-L-galactose. The investigation of probiotic effects in vitro revealed that VAG could promote the growth of B. thetaiotaomicron and B. ovatus, while had no effect on the growth of L. acidophilus, L. rhamnosus, B. longum subsp. infantis and B. animalis subsp. lactis, but dVAG-3 with Mw-1.0 kDa could promote the growth of L. acidophilus. These results will provide insights into specific structures and functions of polysaccharides from the V. alte.
关键词Slug Galactan Chemical structure Oligosaccharide Human gut microbiota SULFATED GALACTANS HELIX-POMATIA POLYSACCHARIDES BIOACTIVITY HYDROLYSIS
学科领域Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
DOI10.1016/j.ijbiomac.2023.123935
收录类别SCI
WOS记录号WOS:000959437500001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/75579
专题中国科学院昆明植物研究所
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Zuo,Zhichuang,He,Zhicheng,Ma,Yan,et al. Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,236:123935.
APA Zuo,Zhichuang.,He,Zhicheng.,Ma,Yan.,Xu,Chen.,Tao,Xuelin.,...&Zhao,Jinhua.(2023).Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,236,123935.
MLA Zuo,Zhichuang,et al."Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 236(2023):123935.
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