KIB OpenIR
Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities
Shang,Chong; Huang,Xiao-Yan; Wang,Yuan; Dong,Wei; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
2023
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0539
摘要Artemongolides A-E (1-5), an unusual class of diseco-guaianolides featuring a rare fused 7-methylbicyclo[2.2.1]-2-ene-7-heptanol ring system, and artemongolide F (6), the first example of [4 + 2] Diels-Alder type adducts presumably incorporating a chain farnesane sesquiterpene and a guaianolide diene, were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the spectroscopic analyses of UV, IR, MS, and 1D and 2D NMR spectra. The absolute configurations of artemongolides A (1) and F (6) were determined by single-crystal X-ray crystallography, and those of artemongolides B-E (2-5) were established by ECD calculations. Cytotoxicity evaluation suggested that compound 1 exhibited activity against HSC-LX2 cells with an IC50 value of 165.0 mu M, equivalent to that of the positive control silybin (IC50, 146.4 mu M). Preliminary mechanism studies revealed that compound 1 could inhibit the deposition of human collagen type I (Col I), human hyaluronic acid (HA), and human laminin (HL) with IC50 values of 123.8, 160.4, and 139.20 mu M.
关键词GUAIANOLIDE LACTONES ARGYI
学科领域Chemistry
DOI10.1039/d2ob02182j
收录类别SCI
WOS记录号WOS:000908291100001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/75543
专题中国科学院昆明植物研究所
推荐引用方式
GB/T 7714
Shang,Chong,Huang,Xiao-Yan,Wang,Yuan,et al. Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023.
APA Shang,Chong.,Huang,Xiao-Yan.,Wang,Yuan.,Dong,Wei.,He,Xiao-Feng.,...&Chen,Ji-Jun.(2023).Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities.ORGANIC & BIOMOLECULAR CHEMISTRY.
MLA Shang,Chong,et al."Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities".ORGANIC & BIOMOLECULAR CHEMISTRY (2023).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1721791192_93846_c89(1085KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shang,Chong]的文章
[Huang,Xiao-Yan]的文章
[Wang,Yuan]的文章
百度学术
百度学术中相似的文章
[Shang,Chong]的文章
[Huang,Xiao-Yan]的文章
[Wang,Yuan]的文章
必应学术
必应学术中相似的文章
[Shang,Chong]的文章
[Huang,Xiao-Yan]的文章
[Wang,Yuan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1721791192_93846_c89b0d3044d8c15214b07b605c25e635_1721791124.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。