Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities

doi:10.1039/d2ob02182j

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	Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities
	Shang,Chong; Huang,Xiao-Yan; Wang,Yuan; Dong,Wei; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
	2023
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0539
摘要	Artemongolides A-E (1-5), an unusual class of diseco-guaianolides featuring a rare fused 7-methylbicyclo[2.2.1]-2-ene-7-heptanol ring system, and artemongolide F (6), the first example of [4 + 2] Diels-Alder type adducts presumably incorporating a chain farnesane sesquiterpene and a guaianolide diene, were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the spectroscopic analyses of UV, IR, MS, and 1D and 2D NMR spectra. The absolute configurations of artemongolides A (1) and F (6) were determined by single-crystal X-ray crystallography, and those of artemongolides B-E (2-5) were established by ECD calculations. Cytotoxicity evaluation suggested that compound 1 exhibited activity against HSC-LX2 cells with an IC50 value of 165.0 mu M, equivalent to that of the positive control silybin (IC50, 146.4 mu M). Preliminary mechanism studies revealed that compound 1 could inhibit the deposition of human collagen type I (Col I), human hyaluronic acid (HA), and human laminin (HL) with IC50 values of 123.8, 160.4, and 139.20 mu M.
关键词	GUAIANOLIDE LACTONES ARGYI
学科领域	Chemistry
DOI	10.1039/d2ob02182j
收录类别	SCI
WOS记录号	WOS:000908291100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75543
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Shang,Chong,Huang,Xiao-Yan,Wang,Yuan,et al. Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023.
APA	Shang,Chong.,Huang,Xiao-Yan.,Wang,Yuan.,Dong,Wei.,He,Xiao-Feng.,...&Chen,Ji-Jun.(2023).Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities.ORGANIC & BIOMOLECULAR CHEMISTRY.
MLA	Shang,Chong,et al."Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities".ORGANIC & BIOMOLECULAR CHEMISTRY (2023).

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