Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis

doi:10.1039/d3ob01724a

KIB OpenIR

	Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis
	Qianshi,Yunhua; Huang,Lei; Jin,Jun; Li,Yanmei; Li,Yanan; Hao,Xiaojiang; Yuan,Chunmao
	2023
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0539
卷号	21 期号:48 页码:9640-9646
摘要	Belchinoids A-C (1-3), three unusual nor-sesquiterpenoids, along with a new isoflavone (4), were isolated from the roots of Belamcanda chinensis, a traditional Chinese medicine. To the best of our knowledge, compound 1 represents the first C13 nor-sesquiterpenoid with a five membered carbon ring. Compounds 2 and 3 are rare C14 chained nor-sesquiterpenoids. Their structures were fully characterized based on extensive spectroscopic data and quantum chemistry calculation. Three compounds (1, 2, and 4) showed potent inhibitory effects on lipid accumulation in an oleic acid-treated HepG2 cell model. In particular, compound 2 exhibited the most potent inhibitory effect on triglyceride accumulation at a low concentration of 2.5 mu M, better than the positive control atorvastatin. The plausible biosynthetic pathway of the three nor-sesquiterpenoids (1-3) is also proposed.
DOI	10.1039/d3ob01724a
收录类别	SCI
WOS记录号	WOS:001116599200001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75542
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Qianshi,Yunhua,Huang,Lei,Jin,Jun,et al. Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(48):9640-9646.
APA	Qianshi,Yunhua.,Huang,Lei.,Jin,Jun.,Li,Yanmei.,Li,Yanan.,...&Yuan,Chunmao.(2023).Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis.ORGANIC & BIOMOLECULAR CHEMISTRY,21(48),9640-9646.
MLA	Qianshi,Yunhua,et al."Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis".ORGANIC & BIOMOLECULAR CHEMISTRY 21.48(2023):9640-9646.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
1721791305_53768_764（735KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载