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Artemannuols A-C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua
He,Xiao-Feng; Wang,Meng-Fei; Li,Tian-Ze; Ma,Yun-Bao; Chen,Ji-Jun
2023
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0539
卷号21期号:26页码:5451-5456
摘要

Artemisia annua, also known as Qinghao in Chinese, is a famous traditional Chinese medicine and has been used for the treatment of malaria and various tumors. In this study, three novel sesquiterpenoidflavonol hybrids, artemannuols A-C (1-3), were isolated and elucidated by extensive spectral data and ECD calculations. Structurally, artemannuols A-C (1-3) are the first examples of sesquiterpenoid-flavonol hybrids fused by an ether bond, among which artemannuols A and B (1 and 2) are composed of bisabolane-type sesquiterpenoid and flavonol moieties, and artemannuol C (3) is composed of humulane-type sesquiterpenoid and flavonol moieties. The antihepatoma assay suggested that compounds 1-3 showed inhibitory effects against HepG2, Huh7, and SK-Hep-1 cell lines with IC50 values in the range of 32.7 to 70.4 mu M.

关键词Hepatocellular-carcinoma Aggregation Pheromone Bug
DOI10.1039/d3ob00780d
收录类别SCI
WOS记录号WOS:001015075400001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/75541
专题中国科学院昆明植物研究所
推荐引用方式
GB/T 7714
He,Xiao-Feng,Wang,Meng-Fei,Li,Tian-Ze,et al. Artemannuols A-C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(26):5451-5456.
APA He,Xiao-Feng,Wang,Meng-Fei,Li,Tian-Ze,Ma,Yun-Bao,&Chen,Ji-Jun.(2023).Artemannuols A-C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua.ORGANIC & BIOMOLECULAR CHEMISTRY,21(26),5451-5456.
MLA He,Xiao-Feng,et al."Artemannuols A-C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua".ORGANIC & BIOMOLECULAR CHEMISTRY 21.26(2023):5451-5456.
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