Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes

doi:10.1016/j.fitote.2022.105379

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	Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes
	Yang,Min-Jie; Luo,Shi-Hong; Guo,Kai; Liu,Yan; Li,Sheng-Hong
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	164 页码:105379
摘要	Buddleja officinalis is a traditional Chinese medicinal plant covered with glandular and non-glandular trichomes on leaves. Phytochemical investigation of its leaves led to the identification of one undescribed tetranorcy-cloartane 3-oxo-25,26,27,29-tetranorcycloartan-24-oic acid (1) and one first identified natural product tetra-norcycloartane 3-oxo-25,26,27,29-tetranorcycloartan-24-oic methyl ester (2), along with an undescribed megastigmane glucoside (3) and 14 known constituents (4-17). Structures of undescribed chemicals were elucidated by comprehensive 1D and 2D NMR, MS and CD analysis. Further chemical investigation resulted in six triterpenoids (4-9) being localized to the trichomes of B. officinalis. The major trichome components cyclo-eucalenone (4) and 24-oxo-29-norcycloartan-3-one (5) showed potent antifeedant activity against a generalist insect cotton bollworm (Helicoverpa armigera), but no obvious activity against the specialist herbivore Hyphasis inconstans. Compounds 4 and 7 also displayed inhibitory effects on seed germination of Arabidopsis thaliana. In addition, 1 and 4 exhibited moderate antibacterial activity toward three gram-positive bacteria.
关键词	Buddleja officinalis Triterpenoids Norcycloartanes Glandular trichomes Chemical defense CONSTITUENTS GLYCOSIDES HARBOR C-13
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2022.105379
收录类别	SCI
WOS记录号	WOS:000895484400019
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75521
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang,Min-Jie,Luo,Shi-Hong,Guo,Kai,et al. Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes[J]. FITOTERAPIA,2023,164:105379.
APA	Yang,Min-Jie,Luo,Shi-Hong,Guo,Kai,Liu,Yan,&Li,Sheng-Hong.(2023).Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes.FITOTERAPIA,164,105379.
MLA	Yang,Min-Jie,et al."Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes".FITOTERAPIA 164(2023):105379.

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