Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus

doi:10.1016/j.fitote.2023.105427

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	Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus
	Xu,Zhi-Hong; Luo,Yang; Qiu,Yu-Feng; Yang,Xing-Wei; Lan,Tian
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	165 页码:105427
摘要	Our continuous study of the dry fruits of Garcinia xanthochymus led to the isolation and structural characterization of four new prenylated acylphloroglucinols, xanthochymusones J-M (1-4), together with the known polycyclic polyprenylated acylphloroglucinols, garciniagifolone A (5) and garcinialiptone A (6). Their structures were elucidated by interpretation of NMR and MS spectroscopic data. Compound 1 bearing a similar core to that of hulupinic acid should be derived via oxidization and ring contraction of prenylated acylphloroglucinol. The inhibitory activities of all the compounds against three human hepatocellular carcinoma cell lines Huh-7, Hep 3B, and Hep G2 were evaluated, and compounds 4 and 5/6 exhibited moderate cytotoxic activities against Hep G2 cells with IC50 values10.4 and 8.8 mu M.
关键词	Garcinia xanthochymus Xanthochymusone Structural determination Cytotoxicity PHLOROGLUCINOL DERIVATIVES BENZOPHENONES XANTHONES
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2023.105427
收录类别	SCI
WOS记录号	WOS:000923041900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75516
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xu,Zhi-Hong,Luo,Yang,Qiu,Yu-Feng,et al. Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus[J]. FITOTERAPIA,2023,165:105427.
APA	Xu,Zhi-Hong,Luo,Yang,Qiu,Yu-Feng,Yang,Xing-Wei,&Lan,Tian.(2023).Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus.FITOTERAPIA,165,105427.
MLA	Xu,Zhi-Hong,et al."Prenylated acylphloroglucinols from the fruits of Garcinia xanthochymus".FITOTERAPIA 165(2023):105427.

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