New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology

doi:10.1016/j.fitote.2023.105491

KIB OpenIR

	New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology
	Dong,Wei; Yang,Ke-Xin; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	167 页码:105491
摘要	Fractionation of the ethanol extract of Artemisia verlotorum led to the identification of eight undescribed eudesmane-type sesquiterpenoids, artemverlolides A-H (1-8). Their structures were determined by spectral analyses (HRESIMS, 1D and 2D NMR, IR, and ECD). Network pharmacology predicted that compounds 1-8 might be target on AURKA, CCNA2, CYP2C19, and EPHX2 with possibly antihepatoma effect from Swiss TargetPrediction and Gene Expression Omnibus database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the targets significantly enriched in FoxO signaling pathway. The molecular docking suggested that compound 8 had high binding affinity with AURKA. Furthermore, the interaction between compound 8 and AURKA was determined by Surface Plasmon Resonance (SPR) assay. The result suggested that compound 8 bound to AURKA with KD value of 68.0 mu M and was consistent with the predicted data, demonstrating that AURKA might be one of acting targets of 8.
关键词	Artemisia verlotorum Eudesmanolides Network pharmacology Molecular docking Surface Plasmon Resonance AURORA KINASE SESQUITERPENOIDS AURKA EXPRESSION
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2023.105491
收录类别	SCI
WOS记录号	WOS:000969960900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75513
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Dong,Wei,Yang,Ke-Xin,He,Xiao-Feng,et al. New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology[J]. FITOTERAPIA,2023,167:105491.
APA	Dong,Wei,Yang,Ke-Xin,He,Xiao-Feng,Li,Tian-Ze,&Chen,Ji-Jun.(2023).New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology.FITOTERAPIA,167,105491.
MLA	Dong,Wei,et al."New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology".FITOTERAPIA 167(2023):105491.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
1-s2.0-S0367326X2300（10566KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载