Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides

doi:10.1016/j.cclet.2022.08.017

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	Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides
	Zhao,Jianjun; Du,Shuzong; Hu,Kun; Hu,Yali; Xia,Fan; Ye,Yansong; Yang,Jian; Nian,Yin; Xu,Gang
	2023
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1878-5964
卷号	34 期号:4 页码:107737
摘要	Nineteen diterpenoids, including saldigitin A ( 1 ) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes ( 2 , 3 ), and two new nor-abietanes ( 5 , 6 ) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data, X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abi-etane skeleton. Biologically, 1 -5 exhibited noticeable inhibitions on Cav 3.1 low voltage-gated Ca2 + channel (LVGCC), with IC50 values in the range of 3.43-11.70 mu mol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Cav 3.1 antagonists. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
关键词	10-Methylated 6 7 6 carbon ring system Icetexane Diterpenoid Salvia digitaloides Ca v 3 1 low voltage -gated Ca 2+channel (LVGCC) ROOTS TANSHINLACTONE CONSTITUENTS ELUCIDATION INHIBITORS CHANNELS SKELETON SYSTEM
学科领域	Chemistry
DOI	10.1016/j.cclet.2022.08.017
收录类别	SCI
WOS记录号	WOS:000961376200001
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75456
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhao,Jianjun,Du,Shuzong,Hu,Kun,et al. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides[J]. CHINESE CHEMICAL LETTERS,2023,34(4):107737.
APA	Zhao,Jianjun.,Du,Shuzong.,Hu,Kun.,Hu,Yali.,Xia,Fan.,...&Xu,Gang.(2023).Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides.CHINESE CHEMICAL LETTERS,34(4),107737.
MLA	Zhao,Jianjun,et al."Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides".CHINESE CHEMICAL LETTERS 34.4(2023):107737.

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