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| Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides | |
Zhao,Jianjun; Du,Shuzong; Hu,Kun ; Hu,Yali; Xia,Fan; Ye,Yansong; Yang,Jian; Nian,Yin; Xu,Gang
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| 2023 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1878-5964 |
| Volume | 34Issue:4Pages:107737 |
| Abstract | Nineteen diterpenoids, including saldigitin A ( 1 ) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes ( 2 , 3 ), and two new nor-abietanes ( 5 , 6 ) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data, X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abi-etane skeleton. Biologically, 1 -5 exhibited noticeable inhibitions on Cav 3.1 low voltage-gated Ca2 + channel (LVGCC), with IC50 values in the range of 3.43-11.70 mu mol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Cav 3.1 antagonists. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| Keyword | 10-Methylated 6 7 6 carbon ring system Icetexane Diterpenoid Salvia digitaloides Ca v 3 1 low voltage -gated Ca 2+channel (LVGCC) ROOTS TANSHINLACTONE CONSTITUENTS ELUCIDATION INHIBITORS CHANNELS SKELETON SYSTEM |
| Subject Area | Chemistry |
| DOI | 10.1016/j.cclet.2022.08.017 |
| Indexed By | SCI |
| WOS ID | WOS:000961376200001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/75456 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Zhao,Jianjun,Du,Shuzong,Hu,Kun,et al. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides[J]. CHINESE CHEMICAL LETTERS,2023,34(4):107737. |
| APA | Zhao,Jianjun.,Du,Shuzong.,Hu,Kun.,Hu,Yali.,Xia,Fan.,...&Xu,Gang.(2023).Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides.CHINESE CHEMICAL LETTERS,34(4),107737. |
| MLA | Zhao,Jianjun,et al."Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides".CHINESE CHEMICAL LETTERS 34.4(2023):107737. |
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| 1-s2.0-S100184172200（1277KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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