Knowledge Management System of Kunming Institute of Botany,CAS
| Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells | |
| Zhang,Xiong; Peng,Ming-You; Feng,En-Ming; Li,Qing-Dan; Chen,Lu; Yang,Hu-Cheng; Guo,Bing; Liang,Hong; Di,Ying-Tong; Tang,Lei; Yan,Ying | |
| 2023 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1880 |
| 摘要 | Three previously undescribed diterpenoids, helioscopnoids A-C, and eight known compounds were isolated from the whole plants of Euphorbia helioscopia. Their structures were established by extensive analysis of spectra and data comparison with previous literatures. Among them, compound 4 was identified as 24,24-dimethoxy-25,26,27-trinoreuphan-3 beta-ol with revised configurations of C-13, C-14, and C-17 (13R*, 14R*, 17R*). Cytotoxicity assays revealed that all compounds exhibited varying levels of cytotoxicity against H1975 cells, with compound 9 displaying the most potent activity, as indicated by cell viability rates of 18.13 % and 20.76 % at concentrations of 20 mu M and 5 mu M, respectively. This study expands the understanding of E. helioscopia terpenoids' structural diversity and biological activities, contributing to the exploration of potential therapeutic applications. |
| 关键词 | Euphorbiaceae Euphorbia helioscopia terpenoids structural elucidation cytotoxic activities DITERPENOIDS |
| DOI | 10.1002/cbdv.202301061 |
| 收录类别 | SCI |
| WOS记录号 | WOS:001079042500001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/75446 |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang,Xiong,Peng,Ming-You,Feng,En-Ming,et al. Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells[J]. CHEMISTRY & BIODIVERSITY,2023. |
| APA | Zhang,Xiong.,Peng,Ming-You.,Feng,En-Ming.,Li,Qing-Dan.,Chen,Lu.,...&Yan,Ying.(2023).Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells.CHEMISTRY & BIODIVERSITY. |
| MLA | Zhang,Xiong,et al."Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells".CHEMISTRY & BIODIVERSITY (2023). |
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