Four new phenolic compounds from the fruits of Alpinia galanga

doi:10.1016/j.phytol.2023.04.001

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	Four new phenolic compounds from the fruits of Alpinia galanga
	Liu,Pei; Wu,Sheng-Li; Wang,Tian; Zhang,Xue-Mei; Geng,Chang-An
	2023
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1876-7486
卷号	55 页码:75-79
摘要	Eleven phenolic compounds including four new ones, (R)-4-(1-methoxypropyl)phenol (1), (S)-3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diyldiacetate (2), (R)-3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diyldiacetate (3) and 3 '-demethoxycrataegusanoid E (4), were isolated from the fruits of Alpinia galanga. The structures of new compounds were elucidated on the basis of extensive spectroscopic data (1D and 2D NMR, [alpha]D, HRESIMS, UV and IR). All the isolates were assayed for their antidiabetic potency against PTP1B and alpha-glycosidase enzymes, and glucagon-like peptide-1 (GLP-1) promotion. Compound 4 showed significant inhibition on PTP1B with an IC50 value of 58.4 mu M, and compound 6 showed alpha-glycosidase inhibitory activity with an IC50 value of 97.6 mu M. Compounds 1-4 and 7-11 could stimulate GLP-1 secretion in NCl-H716 cells with promoting rates of 770.5-1943.1 % (50 mu M). This study provides information for understanding the antidiabetic constituents of A. galanga.
关键词	Alpinia galanga Phenolic compounds PTP1B inhibitory activity ?-glycosidase inhibitory activity GLP-1 secretion
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1016/j.phytol.2023.04.001
收录类别	SCI
WOS记录号	WOS:000982454800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75424
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Liu,Pei,Wu,Sheng-Li,Wang,Tian,et al. Four new phenolic compounds from the fruits of Alpinia galanga[J]. PHYTOCHEMISTRY LETTERS,2023,55:75-79.
APA	Liu,Pei,Wu,Sheng-Li,Wang,Tian,Zhang,Xue-Mei,&Geng,Chang-An.(2023).Four new phenolic compounds from the fruits of Alpinia galanga.PHYTOCHEMISTRY LETTERS,55,75-79.
MLA	Liu,Pei,et al."Four new phenolic compounds from the fruits of Alpinia galanga".PHYTOCHEMISTRY LETTERS 55(2023):75-79.

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