Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

doi:10.1002/cjoc.202300166

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	Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway
	Dong,Wei; Ma,Wen-Jing; Ma,Yun-Bao; Li,Feng-Jiao; Li,Tian-Ze; Wang,Yong-Cui; He,Xiao-Feng; Geng,Chang-An; Zhang,Xue-Mei; Chen,Ji-Jun
	2023
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1614-7065
卷号	41 期号:19 页码:2453-2468
摘要	17 new guaiane-type sesquiterpenoid dimers (GSDs), artemzhongdianolides B1-B17 (1-17), were isolated from Artemisia zhongdianensis under the guidance of bioassay, and elucidated by spectral analyses (HRESIMS, 1D and 2D NMR, IR, ECD). The absolute configuration of compounds 1, 3, 7, 9, 10, and 13 was determined by single-crystal X-ray diffraction analyses. Structurally, artemzhongdianolides B1 (1) and B2 (2) were the first example of the GSDs fused via a C-13/C-13' single bond, and artemzhongdianolides B3-B17 were [4 + 2] Diels-Alder adducts of two monomeric guaianolides. Most of the compounds showed antihepatoma cytotoxicity with IC50 values ranging from 9.9 to 170.1 mu mol/L. Importantly, artemzhongdianolide B9 (9) was the most active one against three hepatoma cell lines with IC50 values of 13.1 mu mol/L (HepG2), 19.5 mu mol/L (Huh7), and 19.5 mu mol/L (SK-Hep-1), and dose-dependently inhibited cell migration and invasion, induced G1 cell cycle arrest and cell apoptosis in HepG2 cells. Compound 9 might suppress HepG2 cells via affecting the p38MAPK signaling pathway suggested by machine learning approach, and significantly upregulated expression of phosphorylated p38 validated by Western blot assay.
关键词	Artemzhongdianolides B1-B17 Artemisia zhongdianensis Guaiane-type sesquiterpenoid dimers Antihepatoma activity p38MAPK pathway Cancer NMR spectroscopy X-ray diffraction ARREST CELLS JNK
DOI	10.1002/cjoc.202300166
收录类别	SCI
WOS记录号	WOS:001019493900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75320
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Dong,Wei,Ma,Wen-Jing,Ma,Yun-Bao,et al. Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway[J]. CHINESE JOURNAL OF CHEMISTRY,2023,41(19):2453-2468.
APA	Dong,Wei.,Ma,Wen-Jing.,Ma,Yun-Bao.,Li,Feng-Jiao.,Li,Tian-Ze.,...&Chen,Ji-Jun.(2023).Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway.CHINESE JOURNAL OF CHEMISTRY,41(19),2453-2468.
MLA	Dong,Wei,et al."Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway".CHINESE JOURNAL OF CHEMISTRY 41.19(2023):2453-2468.

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