Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo

doi:10.1021/acs.jafc.2c08949

KIB OpenIR

	Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo
	Wang,Zhao-Jie; Chen,Yi-Chi; Zou,Feng-Cai; Qin,Yan; Zhu,Yan-Yan; Xiao,Xia; Xie,Tian-Zhen; He,Ying-Jie; Zhao,Yun-li; Luo,Xiao-Dong
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	71 期号:13 页码:5219-5229
摘要	Zanthoxylum plants (ZPs), including multiple Chinese prickly ash species, are dual-purpose functional foods favored by the general population around the world in foods, cosmetics, and traditional medicines and have antipruritic, insecticidal, and fungicidal bioactivities. For the first time, the anti-roundworm bioactivity of ZPs and the active ingredients were compared and investigated. Through nontarget metabolomics following targeted quantitative analysis, qinbunamides, sanshools, sanshooel, asarinin, and sesamin were found to be the main different components of Zanthoxylum species. Coincidentally, the 12 chemical components were also the dominant anti-roundworm ingredients of ZP extracts. The extracts of three species of Chinese prickly ash (1 mg/mL) decreased the hatchability of roundworm eggs significantly, and the ChuanJiao seed killed roundworms (insecticidal rate 100%) and alleviated the symptoms of pneumonia in mice. Furthermore, retention time-accurate mass-tandem mass spectrometry-ion ratio (RT-AM-MS/MS-IR) were modeled by assaying 108 authentic compounds of ZP extracts, and 20 metabolites were confidently identified in biological samples from ZP extract-treated mice by analyzing the m/z values and the empirical substructures. This study provides a good reference for the proper application of ZPs.
关键词	Zanthoxylum plants anti-roundworm high-resolution mass spectrometry collision energy metabolites
学科领域	Agriculture ; Chemistry ; Food Science & Technology
DOI	10.1021/acs.jafc.2c08949
收录类别	SCI
WOS记录号	WOS:000959749800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75303
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Zhao-Jie,Chen,Yi-Chi,Zou,Feng-Cai,et al. Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(13):5219-5229.
APA	Wang,Zhao-Jie.,Chen,Yi-Chi.,Zou,Feng-Cai.,Qin,Yan.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2023).Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(13),5219-5229.
MLA	Wang,Zhao-Jie,et al."Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.13(2023):5219-5229.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1021_acs.jafc.2c0（8638KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载