Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids

doi:10.1039/d3np00006k

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	Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids
	Peng,Xing-Rong; Unsicker,Sybille B.; Gershenzon,Jonathan; Qiu,Ming-Hua
	2023
发表期刊	NATURAL PRODUCT REPORTS
ISSN	1460-4752
摘要	Meroterpenoids found in fungal species of the genus Ganoderma and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1,2,4-trisubstituted benzene and a polyunsaturated side chain. These substances have attracted the attention of chemists and pharmacologists due to their diverse structures and significant bioactivity. In this review, we present the structures and possible biosynthesis of representative GMs newly found from 2018 to 2022, as well as chemical synthesis and biological activity of some interesting GMs. We propose for the first time a plausible biosynthetic pathway for GMs, which will certainly motivate further research on the biosynthetic pathway in Ganoderma species, as well as on chemical synthesis of GMs as important bioactive compounds for the purpose of drug development.
关键词	ENANTIOSELECTIVE TOTAL-SYNTHESIS INDUCED INSULIN-RESISTANCE FRUITING BODIES POLYCYCLIC MEROTERPENOIDS INHIBITORY MEROTERPENOIDS GANOMYCIN I
学科领域	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
DOI	10.1039/d3np00006k
收录类别	SCI
WOS记录号	WOS:000969184700001
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75275
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Peng,Xing-Rong,Unsicker,Sybille B.,Gershenzon,Jonathan,et al. Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids[J]. NATURAL PRODUCT REPORTS,2023.
APA	Peng,Xing-Rong,Unsicker,Sybille B.,Gershenzon,Jonathan,&Qiu,Ming-Hua.(2023).Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids.NATURAL PRODUCT REPORTS.
MLA	Peng,Xing-Rong,et al."Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids".NATURAL PRODUCT REPORTS (2023).

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