Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)

doi:10.1590/0001-3765202320220427

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	Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)
	Meurer,Mariane; Felisbino,Fabiula; Mueller,Fabiana B.; Somensi,Lincon B.; Cury,Benhur J.; Jeronimo,Daniele T.; Venzon,Larissa; Franca,Tauani C. S.; Mariott,Mariha; Santos,Ana C.; Nunes,Ruan Kaio S.; Boeing,Thaise; Bella-Cruz,Alexandre; De Souza,Priscila; Roman-junior,Waltera.; Arunachalam,Karuppusamy; Oliveira,Ruberlei G.; Silva,Luisa M.
	2023
发表期刊	ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
ISSN	1678-2690
卷号	95 页码:e20220427
摘要	The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol-or indomethacininduced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, & alpha;2 adrenergic receptors, and prostaglandins, but not antisecretory or anti -H. pylori properties.
关键词	lutein gastric ulcer oxidative stress phytotherapy H pylori GASTRIC-MUCOSAL LESIONS METHANOLIC EXTRACT OXIDATIVE STRESS NITRIC-OXIDE ULCER PROSTAGLANDINS ANTIOXIDANT BARK SULFHYDRYLS FRUITS
DOI	10.1590/0001-3765202320220427
WOS记录号	WOS:001049037000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74960
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Meurer,Mariane,Felisbino,Fabiula,Mueller,Fabiana B.,et al. Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)[J]. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS,2023,95:e20220427.
APA	Meurer,Mariane.,Felisbino,Fabiula.,Mueller,Fabiana B..,Somensi,Lincon B..,Cury,Benhur J..,...&Silva,Luisa M..(2023).Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.).ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS,95,e20220427.
MLA	Meurer,Mariane,et al."Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.)".ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS 95(2023):e20220427.

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