Discovery of novel phenanthridone derivatives with anti-streptococcal activity

doi:10.1007/s00203-023-03705-7

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	Discovery of novel phenanthridone derivatives with anti-streptococcal activity
	Zhang,Shidan; Zhang,Shiyu; Wang,Yiting; Zhang,Yumin; Liang,Song; Fan,Shirui; Chen,Duozhi; Liu,Guangjin
	2023
发表期刊	ARCHIVES OF MICROBIOLOGY
ISSN	1432-072X
卷号	205 期号:12 页码:371
摘要	To address the growing health threat posed by drug-resistant pathogenic microorganisms, the development of novel antimicrobial medications with multiple mechanisms of action is in urgent demand. With traditional antibacterial drug resources challenging to push forward, developing new antibacterial drugs has become a hot spot in biomedical research. In this study, we tested the antibacterial activity of 119 phenanthridine derivatives via the antibacterial assay and obtained 5 candidates. The cytotoxicity assay showed one phenanthridine derivative, HCK20, was safe for mammalian cells below 125 mu M. HCK20 was verified to possess significant antibacterial activity to Streptococcus spp., such as Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus suis, Streptococcus dysgalactiae, and Streptococcus equi with MICs ranging from 15 to 60 mu M. Furthermore, we found that HCK20 probably achieved its bacterial inhibition by influencing the permeability of bacterial cell walls via interacting with Streptococcal penicillin-binding proteins (PBPs). Our results suggest that this phenanthridine derivative, HCK20, has great potential to become a novel antibacterial agent that can be a potent treatment for streptococcal infections.
关键词	Phenanthridine derivatives Cytotoxicity Antibacterial activity Streptococci Molecular docking RESISTANCE CYTOTOXICITY OPTIMIZATION DOCKING TRENDS
DOI	10.1007/s00203-023-03705-7
WOS记录号	WOS:001097031600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74799
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang,Shidan,Zhang,Shiyu,Wang,Yiting,et al. Discovery of novel phenanthridone derivatives with anti-streptococcal activity[J]. ARCHIVES OF MICROBIOLOGY,2023,205(12):371.
APA	Zhang,Shidan.,Zhang,Shiyu.,Wang,Yiting.,Zhang,Yumin.,Liang,Song.,...&Liu,Guangjin.(2023).Discovery of novel phenanthridone derivatives with anti-streptococcal activity.ARCHIVES OF MICROBIOLOGY,205(12),371.
MLA	Zhang,Shidan,et al."Discovery of novel phenanthridone derivatives with anti-streptococcal activity".ARCHIVES OF MICROBIOLOGY 205.12(2023):371.

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