Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment

doi:10.3390/biomedicines10112841

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	Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment
	He, Zhicheng; Lin, Jian; He, Yingying; Liu, Shubai
	2022
发表期刊	BIOMEDICINES
卷号	10 期号:11 页码:2841
摘要	The incidence and mortality of colorectal cancer have shown an upward trend in the past decade. Therefore, the prevention, diagnosis, and treatment of colorectal cancer still need our continuous attention. Finding compounds with strong anticancer activity and low toxicity is a good strategy for colorectal cancer (CRC) therapy. Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer. Its extractions were demonstrated with strong cell growth inhibitory activity on human colorectal tumor cells, while the anticancer activity of them is not acted through a direct cytotoxic effect. However, the intricacy and high molecular weight make mechanistic research difficult, which restricts their further application as a medication in clinical cancer treatment. Recent research has discovered a small molecule polysaccharide peptide derived from Trametes versicolor that has a distinct structure after decades of Trametes versicolor investigation. Uncertain molecular weight and a complex composition are problems that have been solved through studies on its structure, and it was demonstrated to have strong anti-proliferation activity on colorectal cancer in vitro and in vivo via interaction with EGFR signaling pathway. It opens up new horizons for research in this field, and these low molecular weight polysaccharide peptides provide a new insight of regulation of colorectal cancer proliferation and have great potential as drugs in the treatment of colorectal cancer.
关键词	Trametes versicolor polysaccharide peptide colorectal cancer traditional medicine PROTEIN-BOUND POLYSACCHARIDE QUEL PS-K CORIOLUS-VERSICOLOR IN-VITRO ANTICANCER ACTIVITY SIGNALING PATHWAY ANTITUMOR CELLS MUSHROOM COMBINATION
DOI	10.3390/biomedicines10112841
收录类别	SCI
WOS记录号	WOS:000894684000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74786
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	He, Zhicheng,Lin, Jian,He, Yingying,et al. Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment[J]. BIOMEDICINES,2022,10(11):2841.
APA	He, Zhicheng,Lin, Jian,He, Yingying,&Liu, Shubai.(2022).Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment.BIOMEDICINES,10(11),2841.
MLA	He, Zhicheng,et al."Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment".BIOMEDICINES 10.11(2022):2841.

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