Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities

doi:10.3390/molecules27051730

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	Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities
	Luo, Han; Qin, Wei; Zhang, Hong; Ren, Fu-Cai; Fang, Wen-Tao; Kong, Qing-Hua; Yang, Liu; Zhang, Jian-Mei; Fang, Cheng-Wu; Hu, Jiang-Miao; Liu, Shou-Jin
	2022
发表期刊	MOLECULES
卷号	27 期号:5 页码:1730
摘要	The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (1-4), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophage cells. Compounds 1, 3 and 10 exhibited significant inhibitory activities with IC50 values of 14.05, 23.48 and 29.23 mu mol.L-1, respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive.
关键词	Rubia cordifolia anthraquinones NO inhibitory activity antibacterial NITRIC-OXIDE MEDICINAL-PLANT CELL-CULTURES L-ARGININE CONSTITUENTS BIOSYNTHESIS DERIVATIVES MECHANISMS DISEASE
DOI	10.3390/molecules27051730
收录类别	SCI
WOS记录号	WOS:000814406700001
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74776
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Luo, Han,Qin, Wei,Zhang, Hong,et al. Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities[J]. MOLECULES,2022,27(5):1730.
APA	Luo, Han.,Qin, Wei.,Zhang, Hong.,Ren, Fu-Cai.,Fang, Wen-Tao.,...&Liu, Shou-Jin.(2022).Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities.MOLECULES,27(5),1730.
MLA	Luo, Han,et al."Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities".MOLECULES 27.5(2022):1730.

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