Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin

doi:10.1007/s13273-021-00206-w

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	Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin
	Zhu, Xiang; Na, Xin; Zeng, Yueqin; Xu, Yangantai; Chai, Dongya; Yang, Huanzhi; Miao, Jingqian; Zhang, Yuan; Yang, Fenghua; Wang, Yuehu; Zhou, Yiping
	2022
发表期刊	MOLECULAR & CELLULAR TOXICOLOGY
卷号	18 期号:3 页码:359-369
摘要	Background Polyphyllin I (PPI), a steroidal saponin, exhibits antitumor activity and chemosensitization effect for a broad spectrum of cancer cells, however, its toxicity and chemosensitization effect in vivo is still unknown. Objective We investigated PPI's cytotoxic activity, toxicity and chemosensitization effect and in vitro and in vivo. Results The IC50 values of PPI on MCF-7, H22, and S180 tumor cells were 4.37 mu mol/L, 1.71 mu mol/L, and 0.92 mu mol/L, respectively. The LD50 of PPI was found to be 47.9 mg/kg using ip. injection. PPI at concentrations of 0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg, and 2.4 mg/kg (1/80 LD50-1/20 LD50) were synergized with DOX of 0.5 mg/kg to inhibit the H22 and S180 tumor growth in vivo by inducing apoptosis without obvious immunotoxicity. PPI exhibited a remarkable hemolytic effect on rabbit erythrocytes (EC50 = 4.3 mu M), while it had no impact in mice. Conclusion Our study revealed that the PPI-sensitized chemotherapeutic effect, when used in safe doses, circumvents immunotoxic side effects of DOX in vivo; thus, helping future clinical research.
关键词	Polyphyllin I Chemosensitization Doxorubicin Immunotoxicity Hemolysis BREAST-CANCER CELLS SAPONIN INHIBITION RESISTANCE CISPLATIN
DOI	10.1007/s13273-021-00206-w
收录类别	SCI
WOS记录号	WOS:000741933200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74770
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhu, Xiang,Na, Xin,Zeng, Yueqin,et al. Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin[J]. MOLECULAR & CELLULAR TOXICOLOGY,2022,18(3):359-369.
APA	Zhu, Xiang.,Na, Xin.,Zeng, Yueqin.,Xu, Yangantai.,Chai, Dongya.,...&Zhou, Yiping.(2022).Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin.MOLECULAR & CELLULAR TOXICOLOGY,18(3),359-369.
MLA	Zhu, Xiang,et al."Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin".MOLECULAR & CELLULAR TOXICOLOGY 18.3(2022):359-369.

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