Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities

doi:10.3390/molecules27227676

KIB OpenIR

	Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities
	Yue, Jingyi; Zhang, Nan; Xu, Tao; Wang, Jutao; Cai, Baixiang; Yu, Yang
	2022
发表期刊	MOLECULES
卷号	27 期号:22 页码:7676
摘要	Three undescribed phenylpropanoid derivatives, including two new bibenzyl constituents (1-2), one new stilbene constituent (3), together with five known compounds stilbostemin F (4), dihydropinosylvin (5), 2-(4-hydroxyphenyl)ethyl benzoate (6), 1-(4-hydroxybenzoyl)ethanone (7), and 4-hydroxy-3-prenylbenzoic acid (8), were isolated from the tuber of Asparagus cochinchinensis. The structures of 1-8 were elucidated according to UV, IR, HRMS, 1D and 2D-NMR methods together with the published literature. All of the isolated compounds were assessed for anti-inflammatory activity by acting on lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells in vitro. The results showed that compounds 2 and 5 were found to inhibit the production of nitric oxide (NO) with the IC50 value of 21.7 and 35.8 mu M, respectively. In addition, further studies found that compound 2 demonstrated concentration-dependent suppression of the protein expression of iNOS and exerted anti-inflammatory activity via the NF-kappa B signalling pathway. The present data suggest that phenylpropanoid derivatives from the tuber of A. cochinchinensis might be used as a potential source of natural anti-inflammatory agents.
关键词	phenylpropanoid Asparagus cochinchinensis anti-inflammatory activity PHENANTHRENE EXTRACT
DOI	10.3390/molecules27227676
收录类别	SCI
WOS记录号	WOS:000888118700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74765
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yue, Jingyi,Zhang, Nan,Xu, Tao,et al. Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities[J]. MOLECULES,2022,27(22):7676.
APA	Yue, Jingyi,Zhang, Nan,Xu, Tao,Wang, Jutao,Cai, Baixiang,&Yu, Yang.(2022).Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities.MOLECULES,27(22),7676.
MLA	Yue, Jingyi,et al."Phenylpropanoid Derivatives from the Tuber of Asparagus cochinchinensis with Anti-Inflammatory Activities".MOLECULES 27.22(2022):7676.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
ARTN 7676.pdf（1326KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载