Gene fusion as an important mechanism to generate new genes in the genus Oryza

doi:10.1186/s13059-022-02696-w

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	Gene fusion as an important mechanism to generate new genes in the genus Oryza
	Zhou, Yanli; Zhang, Chengjun; Zhang, Li; Ye, Qiannan; Liu, Ningyawen; Wang, Muhua; Long, Guangqiang; Fan, Wei; Lon, Manyuan; Wing, Rod A.
	2022
发表期刊	GENOME BIOLOGY
卷号	23 期号:1 页码:130
摘要	Background Events of gene fusion have been reported in several organisms. However, the general role of gene fusion as part of new gene origination remains unknown. Results We conduct genome-wide interrogations of four Oryza genomes by designing and implementing novel pipelines to detect fusion genes. Based on the phylogeny of ten plant species, we detect 310 fusion genes across four Oryza species. The estimated rate of origination of fusion genes in the Oryza genus is as high as 63 fusion genes per species per million years, which is fixed at 16 fusion genes per species per million years and much higher than that in flies. By RNA sequencing analysis, we find more than 44% of the fusion genes are expressed and 90% of gene pairs show strong signals of purifying selection. Further analysis of CRISPR/Cas9 knockout lines indicates that newly formed fusion genes regulate phenotype traits including seed germination, shoot length and root length, suggesting the functional significance of these genes. Conclusions We detect new fusion genes that may drive phenotype evolution in Oryza. This study provides novel insights into the genome evolution of Oryza.
关键词	Fusion gene Oryza Evolutionary patterns Phenotype TRANSPOSABLE ELEMENTS RAPID EVOLUTION CHIMERIC GENES RICE GENOME DUPLICATION EXPRESSION RETROPOSITION ORIGINATION COMPLEXITY GLABERRIMA
DOI	10.1186/s13059-022-02696-w
收录类别	SCI
WOS记录号	WOS:000811758800002
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74744
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou, Yanli,Zhang, Chengjun,Zhang, Li,et al. Gene fusion as an important mechanism to generate new genes in the genus Oryza[J]. GENOME BIOLOGY,2022,23(1):130.
APA	Zhou, Yanli.,Zhang, Chengjun.,Zhang, Li.,Ye, Qiannan.,Liu, Ningyawen.,...&Wing, Rod A..(2022).Gene fusion as an important mechanism to generate new genes in the genus Oryza.GENOME BIOLOGY,23(1),130.
MLA	Zhou, Yanli,et al."Gene fusion as an important mechanism to generate new genes in the genus Oryza".GENOME BIOLOGY 23.1(2022):130.

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