Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity

doi:10.3389/fchem.2021.812564

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	Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity
	Tang, Jun; Huang, Xueshuang; Cao, Ming-Hang; Wang, Zhiyan; Yu, Zhiyin; Yan, Yijun; Huang, Jian-Ping; Wang, Li; Huang, Sheng-Xiong
	2022
Source Publication	FRONTIERS IN CHEMISTRY
Volume	9 Pages:812564
Abstract	During a screening for antifungal secondary metabolites, six new mono-/bis-alkenoic acid derivatives (2-7) and one known alkenoic acid derivative (1) were isolated from an endophytic fungi Scopulariopsis candelabrum. Their chemical structures were identified by H-1-NMR, C-13-NMR, 2D NMR, and high-resolution mass spectrometry, as well as comparisons with previously reported literatures. Among them, fusariumesters C-F (2-5) are bis-alkenoic acid derivatives dimerized by an ester bond, while acetylfusaridioic acid A (6) and fusaridioic acid D (7) are alkenoic acid monomers. All the isolates were submitted to an antifungal assay against Candida albicans and the corn pathogen Exserohilum turcicum using the filter paper agar diffusion method. As a result, only compound 1 decorating with beta-lactone ring turned out to be active against these two tested fungi. The broth microdilution assay against Candida albicans showed the minimum inhibitory concentration (MIC) value of 1 to be 20 mu g/ml, while the minimum inhibitory concentration value of the positive control (naystatin) was 10 mu g/ml. And the half maximal inhibitory concentration (IC50) value (21.23 mu g/ml) of 1 against Exserohilum turcicum was determined by analyzing its inhibition effect on the mycelial growth, using cycloheximide (IC50 = 46.70 mu g/ml) as the positive control.
Keyword	Alkenoic acid derivatives polyketides Microascaceae Scopulariopsis candelabrum antifungal activity Candida albicans COENZYME-A SYNTHASE 3-HYDROXY-3-METHYLGLUTARYL COENZYME NATURAL-PRODUCTS CHOLESTEROL-BIOSYNTHESIS ABSOLUTE-CONFIGURATION ANTIBIOTIC 1233A INHIBITION BINDING F-244
DOI	10.3389/fchem.2021.812564
Indexed By	SCI
WOS ID	WOS:000748037600001
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/74087
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Tang, Jun,Huang, Xueshuang,Cao, Ming-Hang,et al. Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity[J]. FRONTIERS IN CHEMISTRY,2022,9:812564.
APA	Tang, Jun.,Huang, Xueshuang.,Cao, Ming-Hang.,Wang, Zhiyan.,Yu, Zhiyin.,...&Huang, Sheng-Xiong.(2022).Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity.FRONTIERS IN CHEMISTRY,9,812564.
MLA	Tang, Jun,et al."Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity".FRONTIERS IN CHEMISTRY 9(2022):812564.

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