Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity

doi:10.1016/j.phytochem.2021.112859

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	Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity
	Yu,Yang ; Bao,Mei-Fen ; Huang,Sheng-Zhuo ; Wu,Jing ; Cai,Xiang-Hai
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	190 页码:112859
摘要	Thirty-one Vincan-and two Eburnan-type alkaloids were isolated from the aerial parts of Tabernaemontana bovina, whereas 20 of them are described the first time. Within the purified alkaloids, the firstly described taberbovcamine A features a 6/5/6/6/5 ring system. All the chemical structures were elucidated by employing extensive spectroscopic, computational electronic circular dichroism and X-ray diffraction methods. The two Eburnan-type alkaloids, 10,11-dimethoxy-16-O-methyllisoeburnamenine and 10,11-dimethoxy-isoeburnamenine were simultaneously identified by using the mentioned spectroscopic methods. Within the identified alkaloids, 10-hydroxy-14,15-didehydrovincanmine, 14,15-didehydrovincanmine, 14,15-didehydroapovincanmine, and criocerine increased the glucose consumption in a L6 myotube model.
关键词	Tabernaemontana bovina Apocynaceae Vincan-type alkaloids Eburnan-type alkaloids Hypoglycemic activity INDOLE ALKALOIDS
DOI	10.1016/j.phytochem.2021.112859
WOS记录号	WOS:000687218600004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73776
专题	中国科学院昆明植物研究所
作者单位	1.[Yu, Yang 2.Bao, Mei-Fen 3.Wu, Jing 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
推荐引用方式 GB/T 7714	Yu,Yang,Bao,Mei-Fen,Huang,Sheng-Zhuo,et al. Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity[J]. PHYTOCHEMISTRY,2021,190:112859.
APA	Yu,Yang,Bao,Mei-Fen,Huang,Sheng-Zhuo,Wu,Jing,&Cai,Xiang-Hai.(2021).Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity.PHYTOCHEMISTRY,190,112859.
MLA	Yu,Yang,et al."Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity".PHYTOCHEMISTRY 190(2021):112859.

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