Five new secondary metabolites from the fungus Phomopsis asparagi

doi:10.1016/j.fitote.2021.104840

KIB OpenIR

	Five new secondary metabolites from the fungus Phomopsis asparagi
	Zhou,Peng ; Yan,Shan ; Lu,Yuanyuan ; Li,Xiao-Nian ; Zhang,Mi ; Li,Qin ; Chen,Xia ; Wang,Jianping ; Zhu,Hucheng ; Chen,Chunmei ; Zhang,Yonghui
	2021
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	150 页码:104840
摘要	Five new compounds, including a pair of diphenylcyclopentenone enantiomers (+/-)-phomopsisin A (1), a sesquiterpenoid 15-hydroxylithocarin A (2), a new diketopiperazine alkaloid prenylcyclotryprostatin A (3) and 7hydroxy-cis-L(- )-3,6-dibenzyl-2,5-dioxopiperazine (6), along with five known compounds were isolated from the fungus Phomopsis asparagi. Their structures were elucidated on the basis of spectroscopic analyses (1D and 2D NMR), theoretical electronic circular dichroism (ECD) calculation, modified Mosher's method, and X-ray crystallography. The racemates of (+/-)-phomopsisin A showed inhibition on alpha-glucosidase with IC50 of 30.07 +/- 0.75 mu M (positive control acarbose, 121 +/- 2.7 mu M).
关键词	Phomopsis asparagi Diphenylcyclopentenone Diketopiperazine A-glucosidase inhibition ASPERGILLUS-FUMIGATUS STEM BLIGHT DERIVATIVES INHIBITORS
DOI	10.1016/j.fitote.2021.104840
WOS记录号	WOS:000661456300008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73767
专题	中国科学院昆明植物研究所
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Maternal & Child Hlth Hosp Hubei Prov, Wuhan 430070, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhou,Peng,Yan,Shan,Lu,Yuanyuan,et al. Five new secondary metabolites from the fungus Phomopsis asparagi[J]. FITOTERAPIA,2021,150:104840.
APA	Zhou,Peng.,Yan,Shan.,Lu,Yuanyuan.,Li,Xiao-Nian.,Zhang,Mi.,...&Zhang,Yonghui.(2021).Five new secondary metabolites from the fungus Phomopsis asparagi.FITOTERAPIA,150,104840.
MLA	Zhou,Peng,et al."Five new secondary metabolites from the fungus Phomopsis asparagi".FITOTERAPIA 150(2021):104840.