Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis

doi:10.1016/j.bioorg.2021.105237

KIB OpenIR

	Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis
	Liu,Bo ; Li,Bingxin ; Zhou,Di ; Wen,Xiaoyan ; Wang,Yajun ; Chen,Gang ; Li,Ning
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	115 页码:105237
摘要	In the ongoing research on potent antitumor agents from the rhizomes of Asparagus cochinchinensis, seven undescribed steroidal saponins asparagusoside A-G (1-7), along with twenty known ones (8-27), were isolated and elucidated via analyzing their 1D, 2D NMR, mass spectroscopic data and chemical methods. All isolated compounds were evaluated for their cytotoxic effects against human large cell lung carcinoma cells (NCI-H460) in vitro. Among them, compounds 7, 9 and 27 showed more significant antitumor activities than the positive control cisplatin (11.56 mu M) with IC50 values of 1.39, 3.04, and 2.25 mu M, respectively. Further research about asparagusoside G (7) showed G(0)/G(1) arrest in NCI-H460 cell line cycle and induced cell death by apoptosis in a dose-dependent way.
关键词	Asparagus cochinchinensis Steroidal NCI-H460 cell line Cytotoxic Apoptosis GLYCOSIDES CELL CANCER
DOI	10.1016/j.bioorg.2021.105237
WOS记录号	WOS:000704036500012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73760
专题	中国科学院昆明植物研究所
作者单位	1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources We, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu,Bo,Li,Bingxin,Zhou,Di,et al. Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis[J]. BIOORGANIC CHEMISTRY,2021,115:105237.
APA	Liu,Bo.,Li,Bingxin.,Zhou,Di.,Wen,Xiaoyan.,Wang,Yajun.,...&Li,Ning.(2021).Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis.BIOORGANIC CHEMISTRY,115,105237.
MLA	Liu,Bo,et al."Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis".BIOORGANIC CHEMISTRY 115(2021):105237.