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Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of Bacillus velezensis W1
Li,Xingyu; Munir,Shahzad; Xu,Yan; Wang,Yuehu; He,Yueqiu
2021
发表期刊RSC ADVANCES
ISSN2046-2069
卷号11期号:41页码:25441-25449
摘要A comprehensive analytic strategy was performed to study the acaricidal activity ingredients of Bacillus velezensis W1, a strain for biological control of Tetranychus urticae. Through genome mining, 14 biosynthetic gene clusters were identified, which encode secondary metabolites, and these were further confirmed by MALDI-TOF-MS or LC-ESI-MS/MS, including bacillomycin D C13-C17, macrolactin A, 7-O-malonyl-macrolactin A, surfactin C14, and surfactin C15. Moreover, 27 volatile compounds were identified by GC-MS, mainly including cyclodipeptides, alkanes, organic acids, and esters. Finally, 43 compounds identified from W1 were used in the virtual screening of acaricidal activity. The results showed that 16 compounds, including cyclodipeptides, bacillomycins, macrolactins, and surfactins, have acaricidal potential. This work provides a base for studying the mechanism of acaricidal action of B. velezensis W1 and a comprehensive strategy for the study of active ingredients from biocontrol strains.
关键词BACILLOMYCIN
DOI10.1039/d1ra01326b
WOS记录号WOS:000678294800029
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73497
专题中国科学院昆明植物研究所
作者单位1.Yunnan Agr Univ, Coll Sci, Kunming 650201, Yunnan, Peoples R China
2.Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA
3.Yunnan Agr Univ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Li,Xingyu,Munir,Shahzad,Xu,Yan,et al. Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of Bacillus velezensis W1[J]. RSC ADVANCES,2021,11(41):25441-25449.
APA Li,Xingyu,Munir,Shahzad,Xu,Yan,Wang,Yuehu,&He,Yueqiu.(2021).Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of Bacillus velezensis W1.RSC ADVANCES,11(41),25441-25449.
MLA Li,Xingyu,et al."Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of Bacillus velezensis W1".RSC ADVANCES 11.41(2021):25441-25449.
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