Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection

doi:10.3390/nu13093198

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	Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection
	He,Yingying ; He,Zhicheng ; Leone,Serena ; Liu,Shubai
	2021
发表期刊	NUTRIENTS
ISSN	2072-6643
卷号	13 期号:9 页码:3198
摘要	Exosomes are abundance in human body fluids like urine, milk and blood. They act a critical role in extracellular and intracellular communication, intracellular trafficking and physiological regulation. Multiple immune-modulatory components, such as proteins, RNAs and carbohydrates (glycoproteins), have been found in human milk exosomes, which play immune-regulatory functions. However, little is known about oligosaccharides in milk exosomes, the free sugars, which act critical roles in the development of infant's immature mucosal immune system. In this study, the profile of milk exosomes encapsulated human milk oligosaccharides (HMOs) was calibrated with characteristic oligosaccharides in colostrum and mature milk, respectively. The exosomes containing human milk oligosaccharides were uptaken by macrophages, which were responsible for the establishment of intestinal immunity. Furthermore, mice pretreated with exosome encapsulated HMOs were protected from AIEC infection and had significantly less LPS-induced inflammation and intestinal damage. Exosome encapsulated milk oligosaccharides are regarded to provide a natural manner for milk oligosaccharides to accomplish their critical functions in modifying newborn innate immunity. The understanding of the interaction between a mother's breastfeeding and the development of an infant's mucosal immune system would be advantageous. The transport of milk oligosaccharides to its target via exosome-like particles appears to be promising.
关键词	HMOs exosome mucosal immunity 2 '-FL macrophages INTESTINAL HOMEOSTASIS MECHANISM VESICLES RECEPTOR CELLS
DOI	10.3390/nu13093198
WOS记录号	WOS:000700141000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73456
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Naples Federico II, Dept Chem Sci, I-80121 Naples, Italy 5.Stn Zool Anton Dohrn, Dipartimento Biol Evoluz Organismi Marini BEOM, Villa Communale, I-80121 Naples, Italy
推荐引用方式 GB/T 7714	He,Yingying,He,Zhicheng,Leone,Serena,et al. Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection[J]. NUTRIENTS,2021,13(9):3198.
APA	He,Yingying,He,Zhicheng,Leone,Serena,&Liu,Shubai.(2021).Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection.NUTRIENTS,13(9),3198.
MLA	He,Yingying,et al."Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection".NUTRIENTS 13.9(2021):3198.

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