Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii

doi:10.1016/j.phytochem.2021.112731

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	Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii
	Wang,Ying ; Liu,Yan-Chun ; Li,Wen-Yuan ; Guo,Kai ; Liu,Yan ; Li,Sheng-Hong
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	186 页码:112731
摘要	The Lamiaceae plant Ajuga forrestii Diels is a traditional Chinese herbal medicine with abundant glandular trichomes (GTs), but their chemistry and biological functions remain uninvestigated. Here, a panel of six highly functionalized neo-clerodane diterpenoids was localized to the peltate GTs of A. forrestii using laser microdissection coupled with HPLC analysis, indicating that the GTs of A. forrestii are an excellent material for the elucidation of the yet unclear biosynthetic pathway of natural neo-clerodane diterpenoids. In addition, four undescribed neo-clerodane diterpenoids with an acyclic C-9 side chain including two pairs of 1:1 mixture of inseparable diastereomers, ajuforrestins D-G, were isolated from the fresh leaves of A. forrestii together with six known compounds. The structures of the undescribed compounds were elucidated by spectroscopic (including 1D and 2D NMR and HR-ESI-MS) analyses. Biological assays indicated that the major GT compound ajugacumbin B and undescribed ajuforrestins D/E showed antifeedant activity against Helicoverpa armigera, suggesting that neo-clerodanes in A. forrestii should be involved in plant defence against insects. Moreover, the abietane diterpenoid ajuforrestin B exhibited significant anti-inflammatory activity on the secretion of interleukin-2 (IL-2) and cytotoxicity against three cancer cell lines, NCI-H1975, HepG2 and MCF-7, suggesting that ajuforrestin B could positively contribute to the therapeutic effects of this traditional Chinese medicine.
关键词	Ajuga forrestii Diels Lamiaceae Glandular trichomes Laser microdissection Diterpenoids Defensive function Antifeedant activity Anti-inflammatory activity Cytotoxicity SESQUITERPENE LACTONES PHYTOCHEMISTRY CONSTITUENTS DECUMBENS HARBOR PLANTS L.
DOI	10.1016/j.phytochem.2021.112731
WOS记录号	WOS:000644703200013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73450
专题	中国科学院昆明植物研究所
作者单位	1.[Wang, Ying 2.Liu, Yan-Chun 3.Li, Wen-Yuan 4.Liu, Yan 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 7.[Guo, Kai 8.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 9.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang,Ying,Liu,Yan-Chun,Li,Wen-Yuan,et al. Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii[J]. PHYTOCHEMISTRY,2021,186:112731.
APA	Wang,Ying,Liu,Yan-Chun,Li,Wen-Yuan,Guo,Kai,Liu,Yan,&Li,Sheng-Hong.(2021).Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii.PHYTOCHEMISTRY,186,112731.
MLA	Wang,Ying,et al."Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii".PHYTOCHEMISTRY 186(2021):112731.

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