Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus

doi:10.24272/j.issn.2095-8137.2020.294

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	Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus
	Zhang,Chuan-Ling ; Li,Yi-Jia ; Lu,Shuang ; Zhang,Ting ; Xiao,Rui ; Luo,Huai-Rong
	2021
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	42 期号:1 页码:28-42
摘要	Depression is a prevalent mental disorder that is associated with aging and contributes to increased mortality and morbidity. The overall prevalence of geriatric depression with clinically significant symptoms is currently on the rise. Recent studies have demonstrated that altered expressions of long non-coding RNAs (lncRNAs) in the brain affect neurodevelopment and manifest modulating functions during the depression. However, most lncRNAs have not yet been studied. Herein, we analyzed the transcriptome of dysregulated lncRNAs to reveal their expressions in a mouse model exhibiting depressive-like behaviors, as well as their corresponding response following antidepressant fluoxetine treatment. A chronic unpredictable mild stress (CUMS) mouse model was applied. A six-week fluoxetine intervention in CUMS-induced mice attenuated depressive-like behaviors. In addition, differential expression analysis of lncRNAs was performed following RNA-sequencing. A total of 282 lncRNAs (134 up-regulated and 148 down-regulated) were differentially expressed in CUMS-induced mice relative to non-stressed counterparts (P<0.05). Moreover, 370 differentially expressed lncRNAs were identified in CUMS-induced mice after fluoxetine intervention. Gene Ontology (GO) analyses showed an association between significantly dysregulated lncRNAs and protein binding, oxygen binding, and transport activity, while the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that these dysregulated lncRNAs might be involved in inflammatory response pathways. Fluoxetine effectively ameliorated the symptoms of depression in CUMS-induced mice by regulating the expression of lncRNAs in the hippocampus. The findings herein provide valuable insights into the potential mechanism underlying depression in elderly people.
关键词	Depression Elderly Fluoxetine LncRNA Chronic unpredictable mild stress LONG NONCODING RNA NEUROTROPHIC FACTOR MAJOR DEPRESSION MILD STRESS DRUG-NAIVE PROTEIN INFLAMMATION MECHANISMS BIOMARKERS DISCOVERY
DOI	10.24272/j.issn.2095-8137.2020.294
WOS记录号	WOS:000616785200004
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73431
专题	中国科学院昆明植物研究所
作者单位	1.[Zhang, Chuan-Ling 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Inner Mongolia Med Univ, Sch Pharm, Hohhot 010110, Inner Mongolia, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.[Li, Yi-Jia 6.Lu, Shuang 7.Zhang, Ting 8.Inner Mongolia Med Univ, Key Lab Mol Pathol, Hohhot 010059, Inner Mongolia, Peoples R China 9.Southwestern Med Univ, Sch Pharm, Dept Pharmacol, Key Lab Aging & Regenerat Med, Luzhou 646000, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Zhang,Chuan-Ling,Li,Yi-Jia,Lu,Shuang,et al. Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus[J]. ZOOLOGICAL RESEARCH,2021,42(1):28-42.
APA	Zhang,Chuan-Ling,Li,Yi-Jia,Lu,Shuang,Zhang,Ting,Xiao,Rui,&Luo,Huai-Rong.(2021).Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus.ZOOLOGICAL RESEARCH,42(1),28-42.
MLA	Zhang,Chuan-Ling,et al."Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus".ZOOLOGICAL RESEARCH 42.1(2021):28-42.

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