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Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis
Zhang,Quanwei; Liu,Man; Li,Lifeng; Chen,Miaomiao; Puno,Pema Tenzin; Bao,Wanrong; Zheng,Hongming; Wen,Xin; Cheng,Huiyuan; Fung,Hauyee; Wong,Tinlong; Zhao,Zhongzhen; Lyu,Aiping; Han,Quanbin; Sun,Handong
2021
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume271Pages:118443
AbstractCordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity. We newly reported a Cordyceps quality marker CCP (Mw 433.778 kDa) which was characterized as a 1,4-alpha glucan by chemical and spectral analysis and is able to induce significant immune responses of macrophages. Herein, we further investigated the molecular mechanism of CCP's immunomodulatory effects. The results indicate that CCP modulates the TLR4/MyD88/p38 signaling pathway of macrophages, where TLR4 plays a crucial role as verified on TLR4-deficient (TLR4-/-) bone marrow-derived macrophages (BMDMs) and TLR4-/- mice. These findings provide a precise understanding of the molecular mechanism of Cordyceps' immunomodulatory benefits.
KeywordCordyceps Polysaccharide TLR4 MyD88 p38 Immune responses Macrophage NF-KAPPA-B STRUCTURAL-CHARACTERIZATION ANTIOXIDANT ACTIVITY MYCELIAL FERMENTATION SIGNALING PATHWAYS FRUITING BODIES SINENSIS FUNGUS GENE-EXPRESSION LIPOPOLYSACCHARIDE RECOGNITION
DOI10.1016/j.carbpol.2021.118443
WOS IDWOS:000685061700006
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73416
Collection中国科学院昆明植物研究所
Affiliation1.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang,Quanwei,Liu,Man,Li,Lifeng,et al. Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis[J]. CARBOHYDRATE POLYMERS,2021,271:118443.
APA Zhang,Quanwei.,Liu,Man.,Li,Lifeng.,Chen,Miaomiao.,Puno,Pema Tenzin.,...&Sun,Handong.(2021).Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis.CARBOHYDRATE POLYMERS,271,118443.
MLA Zhang,Quanwei,et al."Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis".CARBOHYDRATE POLYMERS 271(2021):118443.
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