Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis

doi:10.1016/j.carbpol.2021.118443

KIB OpenIR

	Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis
	Zhang,Quanwei ; Liu,Man ; Li,Lifeng ; Chen,Miaomiao ; Puno,Pema Tenzin ; Bao,Wanrong ; Zheng,Hongming ; Wen,Xin ; Cheng,Huiyuan ; Fung,Hauyee ; Wong,Tinlong ; Zhao,Zhongzhen ; Lyu,Aiping ; Han,Quanbin ; Sun,Handong
	2021
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	271 页码:118443
摘要	Cordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity. We newly reported a Cordyceps quality marker CCP (Mw 433.778 kDa) which was characterized as a 1,4-alpha glucan by chemical and spectral analysis and is able to induce significant immune responses of macrophages. Herein, we further investigated the molecular mechanism of CCP's immunomodulatory effects. The results indicate that CCP modulates the TLR4/MyD88/p38 signaling pathway of macrophages, where TLR4 plays a crucial role as verified on TLR4-deficient (TLR4-/-) bone marrow-derived macrophages (BMDMs) and TLR4-/- mice. These findings provide a precise understanding of the molecular mechanism of Cordyceps' immunomodulatory benefits.
关键词	Cordyceps Polysaccharide TLR4 MyD88 p38 Immune responses Macrophage NF-KAPPA-B STRUCTURAL-CHARACTERIZATION ANTIOXIDANT ACTIVITY MYCELIAL FERMENTATION SIGNALING PATHWAYS FRUITING BODIES SINENSIS FUNGUS GENE-EXPRESSION LIPOPOLYSACCHARIDE RECOGNITION
DOI	10.1016/j.carbpol.2021.118443
WOS记录号	WOS:000685061700006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73416
专题	中国科学院昆明植物研究所
作者单位	1.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang,Quanwei,Liu,Man,Li,Lifeng,et al. Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis[J]. CARBOHYDRATE POLYMERS,2021,271:118443.
APA	Zhang,Quanwei.,Liu,Man.,Li,Lifeng.,Chen,Miaomiao.,Puno,Pema Tenzin.,...&Sun,Handong.(2021).Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis.CARBOHYDRATE POLYMERS,271,118443.
MLA	Zhang,Quanwei,et al."Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis".CARBOHYDRATE POLYMERS 271(2021):118443.