A specific and bioactive polysaccharide marker for Cordyceps
Li,Li-Feng; But,Grace Wing-Chiu; Zhang,Quan-Wei; Liu,Man; Chen,Miao-Miao; Wen,Xin; Wu,Hoi-Yan; Cheng,Hui-Yuan; Puno,Pema-Tenzin; Zhang,Ji-Xia; Fung,Hau-Yee; Bai,Su-Ping; Wong,Tin-Long; Zhao,Zhong-Zhen; Cao,Hui; Tsim,Karl Wah-Keung; Shaw,Pang-Chui; Han,Quan-Bin; Sun,Han-Dong
AbstractCordyceps is one of the most expensive and widely used functional foods. But the authenticity is still a concern due to the lack of appropriate markers. By targeting polysaccharides, this study aimed to develop a specific, and bioactive marker for Cordyceps. Firstly, the results of screening tests of 250 samples by examining both genetic markers and polysaccharide profile showed that a unique polysaccharide fraction (named CCP) was particular to the caterpillar parts. Its potential as a marker was further demonstrated by its ability to induce NO and cytokine production in RAW 264.7 cells. CCP was characterized to be an alpha-1,4-glucan with a branch at C-6 by the conventional structure analyzing and de novo oligosaccharides sequencing. The content of CCP was closely correlated to the traditional classification criteria. Generally, CCP was a marker that simultaneously enables qualitative and quantitative analysis of Cordyceps.
KeywordCordyceps Polysaccharide Marker Authentication Immune activity STRUCTURAL-ANALYSIS SINENSIS AUTHENTICATION MACROPHAGES SEQUENCE
WOS IDWOS:000678037400007
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Document Type期刊论文
Affiliation1.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Li Dak Sum Yip Yio Chin R & Ctr Chinese Med, Hong Kong, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources We, Kunming, Yunnan, Peoples R China
5.Xinxiang Med Univ, Sch Pharm, Xinxiang, Henan, Peoples R China
6.Jinan Univ, Sch Pharm, Guangzhou, Peoples R China
7.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
8.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Peoples R China
9.Hong Kong Authenticat Ctr Valuable Chinese Med, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li,Li-Feng,But,Grace Wing-Chiu,Zhang,Quan-Wei,et al. A specific and bioactive polysaccharide marker for Cordyceps[J]. CARBOHYDRATE POLYMERS,2021,269:118343.
APA Li,Li-Feng.,But,Grace Wing-Chiu.,Zhang,Quan-Wei.,Liu,Man.,Chen,Miao-Miao.,...&Sun,Han-Dong.(2021).A specific and bioactive polysaccharide marker for Cordyceps.CARBOHYDRATE POLYMERS,269,118343.
MLA Li,Li-Feng,et al."A specific and bioactive polysaccharide marker for Cordyceps".CARBOHYDRATE POLYMERS 269(2021):118343.
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