Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia

doi:10.1055/a-1326-2600

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	Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia
	Song,Hong Chuan ; Qin,Dan ; Liu,Hai Yang ; Dong,Jin Yan ; You,Chuan ; Wang,Yu Meng
	2021
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	87 期号:3 页码:225-235
摘要	Four new beta -resorcylic acid lactones, including penochrochlactone A ( 2 ), 4-O-desmethyl-aigialomycin B ( 4 ), and penochrochlactones C and D ( 5 and 6 ), two compounds isolated from a natural source for the first time, 5 alpha , 6 beta -acetonide-aigialomycin B ( 1 ) and penochrochlactone B ( 3 ), together with six known compounds, aigialomycin F ( 7 ), aigialomycins A, B, and D ( 8 - 10 ), zeaenol ( 11 ), and oxozeaenol ( 12 ), were isolated from a mycelial solid culture of the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia by sequential purification over silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were elucidated by extensive spectroscopic analysis and chemical conversions. In addition, all the new compounds were evaluated for their cytotoxic and antibacterial activities in vitro . Penochrochlactone C ( 5 ) displayed moderate cytotoxicity against the HeLa tumor cell line with an IC (50) value of 9.70 mu M. In the antibacterial assays, compounds 4 - 6 exhibited moderate activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa with MIC values between 9.7 and 32.0 mu g/mL.
关键词	Kadsura angustifolia Schisandraceae resorcylic acid lactones Penicillium ochrochloron cytotoxity antibacterial activity FUNGAL METABOLITES HYPOTHEMYCIN STEREOCHEMISTRY ZEARALENONE MACROLIDES PATHWAY CELLS
DOI	10.1055/a-1326-2600
WOS记录号	WOS:000600588300002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73313
专题	中国科学院昆明植物研究所
作者单位	1.Yunnan Normal Univ, Sch Energy & Environm Sci, 2 Cuihu North Rd, Kunming 650092, Yunnan, Peoples R China 2.Southwest Univ, Sch Life Sci, Minist Educ, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Chongqing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,et al. Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia[J]. PLANTA MEDICA,2021,87(3):225-235.
APA	Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,Dong,Jin Yan,You,Chuan,&Wang,Yu Meng.(2021).Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia.PLANTA MEDICA,87(3),225-235.
MLA	Song,Hong Chuan,et al."Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia".PLANTA MEDICA 87.3(2021):225-235.