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Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia
Song,Hong Chuan; Qin,Dan; Liu,Hai Yang; Dong,Jin Yan; You,Chuan; Wang,Yu Meng
2021
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号87期号:3页码:225-235
摘要Four new beta -resorcylic acid lactones, including penochrochlactone A ( 2 ), 4-O-desmethyl-aigialomycin B ( 4 ), and penochrochlactones C and D ( 5 and 6 ), two compounds isolated from a natural source for the first time, 5 alpha , 6 beta -acetonide-aigialomycin B ( 1 ) and penochrochlactone B ( 3 ), together with six known compounds, aigialomycin F ( 7 ), aigialomycins A, B, and D ( 8 - 10 ), zeaenol ( 11 ), and oxozeaenol ( 12 ), were isolated from a mycelial solid culture of the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia by sequential purification over silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were elucidated by extensive spectroscopic analysis and chemical conversions. In addition, all the new compounds were evaluated for their cytotoxic and antibacterial activities in vitro . Penochrochlactone C ( 5 ) displayed moderate cytotoxicity against the HeLa tumor cell line with an IC (50) value of 9.70 mu M. In the antibacterial assays, compounds 4 - 6 exhibited moderate activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa with MIC values between 9.7 and 32.0 mu g/mL.
关键词Kadsura angustifolia Schisandraceae resorcylic acid lactones Penicillium ochrochloron cytotoxity antibacterial activity FUNGAL METABOLITES HYPOTHEMYCIN STEREOCHEMISTRY ZEARALENONE MACROLIDES PATHWAY CELLS
DOI10.1055/a-1326-2600
WOS记录号WOS:000600588300002
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73313
专题中国科学院昆明植物研究所
作者单位1.Yunnan Normal Univ, Sch Energy & Environm Sci, 2 Cuihu North Rd, Kunming 650092, Yunnan, Peoples R China
2.Southwest Univ, Sch Life Sci, Minist Educ, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Chongqing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
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Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,et al. Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia[J]. PLANTA MEDICA,2021,87(3):225-235.
APA Song,Hong Chuan,Qin,Dan,Liu,Hai Yang,Dong,Jin Yan,You,Chuan,&Wang,Yu Meng.(2021).Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia.PLANTA MEDICA,87(3),225-235.
MLA Song,Hong Chuan,et al."Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia".PLANTA MEDICA 87.3(2021):225-235.
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