Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos

doi:10.1002/cbdv.202100196

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	Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos
	Jiang,Ting-Ting ; Ding,Lin-Fen ; Nie,Wei ; Wang,Liu-Yan ; Lei,Tie ; Wu,Xing-De ; Zhao,Qin-Shi
	2021
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	18 期号:5
摘要	Two unprecedented tetranorlanostane triterpenoids, poricolides A (1) and B (2), and two new lanostane triterpenoids, 3 beta-acetoxy-24-methyllanosta-8,16,24(31)-trien-21-oic acid (3) and 3 beta-acetoxylanosta-7,9(11),16,23-tetraen-21-oic acid (4), were isolated from the epidermis of Poria cocos. The structures of 1-4 were determined via analysis of H-1-, C-13-, and 2D-NMR, and HR-ESI-MS data, and the absolute configurations of 1 and 3 were established by single-crystal X-ray diffraction analysis. Compounds 1 and 2 were the first report of tetranorlanostane triterpenoid having a delta-lactone ring at C(17). Compounds 3 and 4 were rare lanostane triterpenoids having a double bond between C(16) and C(17). Compounds 1-4 exhibited potent antiproliferative effects against A549, SMMC-7721, MCF-7, and SW480 cancer cell lines with IC50 values from 16.19 +/- 0.38 to 27.74 +/- 1.12 mu M.
关键词	Poria cocos lanostane triterpenoid tetranorlanostane triterpenoid cytotoxic activity SURFACE-LAYER EXTRACTS
DOI	10.1002/cbdv.202100196
WOS记录号	WOS:000642321800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73205
专题	中国科学院昆明植物研究所
作者单位	1.[Jiang, Ting-Ting 2.Ding, Lin-Fen 3.Nie, Wei 4.Wang, Liu-Yan 5.Lei, Tie 6.Wu, Xing-De 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 9.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Jiang,Ting-Ting,Ding,Lin-Fen,Nie,Wei,et al. Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos[J]. CHEMISTRY & BIODIVERSITY,2021,18(5).
APA	Jiang,Ting-Ting.,Ding,Lin-Fen.,Nie,Wei.,Wang,Liu-Yan.,Lei,Tie.,...&Zhao,Qin-Shi.(2021).Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos.CHEMISTRY & BIODIVERSITY,18(5).
MLA	Jiang,Ting-Ting,et al."Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos".CHEMISTRY & BIODIVERSITY 18.5(2021).

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