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Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
Fan,Min; Wang,Ting; Peng,Li-Yan; Huang,Jun-Shang; Wu,Xing-De; Wang,He-Yao; Zhao,Qin-Shi
2021
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume18Issue:9Pages:e2100517
AbstractA new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (H-1, C-13, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).
KeywordSalvia hispanica neo-clerodane diterpenoid salvihispin H type 2 diabetes mellitus GLUCOSE-TOLERANCE RISK-FACTORS THERAPY
DOI10.1002/cbdv.202100517
WOS IDWOS:000680807100001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73202
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Dali Univ, Coll Pharm, Dali 671000, Peoples R China
Recommended Citation
GB/T 7714
Fan,Min,Wang,Ting,Peng,Li-Yan,et al. Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.[J]. CHEMISTRY & BIODIVERSITY,2021,18(9):e2100517.
APA Fan,Min.,Wang,Ting.,Peng,Li-Yan.,Huang,Jun-Shang.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L..CHEMISTRY & BIODIVERSITY,18(9),e2100517.
MLA Fan,Min,et al."Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.".CHEMISTRY & BIODIVERSITY 18.9(2021):e2100517.
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