Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.

doi:10.1002/cbdv.202100517

KIB OpenIR

	Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
	Fan,Min; Wang,Ting ; Peng,Li-Yan ; Huang,Jun-Shang ; Wu,Xing-De ; Wang,He-Yao ; Zhao,Qin-Shi
	2021
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	18 期号:9 页码:e2100517
摘要	A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (H-1, C-13, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).
关键词	Salvia hispanica neo-clerodane diterpenoid salvihispin H type 2 diabetes mellitus GLUCOSE-TOLERANCE RISK-FACTORS THERAPY
DOI	10.1002/cbdv.202100517
WOS记录号	WOS:000680807100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73202
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Dali Univ, Coll Pharm, Dali 671000, Peoples R China
推荐引用方式 GB/T 7714	Fan,Min,Wang,Ting,Peng,Li-Yan,et al. Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.[J]. CHEMISTRY & BIODIVERSITY,2021,18(9):e2100517.
APA	Fan,Min.,Wang,Ting.,Peng,Li-Yan.,Huang,Jun-Shang.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L..CHEMISTRY & BIODIVERSITY,18(9),e2100517.
MLA	Fan,Min,et al."Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.".CHEMISTRY & BIODIVERSITY 18.9(2021):e2100517.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
020-B09-227-范敏-CB.pd（1403KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载