Chemical Synthesis of the Nucleoside Antibiotic Capuramycin

doi:10.1002/ejoc.202100613

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	Chemical Synthesis of the Nucleoside Antibiotic Capuramycin
	Xiao,Guozhi; He,Haiqing
	2021
发表期刊	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN	1434-193X
卷号	2021 期号:26 页码:3681-3689
摘要	Capuramycin is an important lead nucleoside antibiotic for the development of new therapeutic agents against the multidrug-resistant Mycobacterium tuberculosis infections. Due to the poor accessibilities, the heterogeneous issues and difficulties in the modification of capuramycin at the specific positions, in-depth studies on the structure-activity relationships (SAR) of capuramycin are hampered. Chemical synthesis is a reliable and effective method to provide capuramycin and its analogues. Thus far, only four different synthetic routes toward capuramycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of capuramycin.
关键词	Capuramycin Chemical synthesis Glycosyl ortho-(1-phenylvinyl)benzoates One-pot glycosylation Tuberculosis DRUG-RESISTANT TUBERCULOSIS GLUTAMIC-ACID-DERIVATIVES MULTIDRUG-RESISTANT PROTECTING GROUPS IN-VITRO GLYCOSYLATION INHIBITORS ALCOHOLS ANALOGS OXIDATION
DOI	10.1002/ejoc.202100613
WOS记录号	WOS:000674246400006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73190
专题	中国科学院昆明植物研究所
作者单位	Univ Chinese Acad Sci, Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Xiao,Guozhi,He,Haiqing. Chemical Synthesis of the Nucleoside Antibiotic Capuramycin[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2021,2021(26):3681-3689.
APA	Xiao,Guozhi,&He,Haiqing.(2021).Chemical Synthesis of the Nucleoside Antibiotic Capuramycin.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2021(26),3681-3689.
MLA	Xiao,Guozhi,et al."Chemical Synthesis of the Nucleoside Antibiotic Capuramycin".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2021.26(2021):3681-3689.

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