Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves

doi:10.1016/j.phytochem.2020.112651

KIB OpenIR

	Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves
	Li,Jin-Feng ; Ji,Kai-Long ; Sun,Peng ; Cai,Qiang ; Zheng,Xiao-Ling ; Xiao,Yi-Dian ; Cao,Dong-Hua ; Xiao,Chun-Fen ; Zhang,Zong-Yi ; Li,Xiao-Nian ; Hu,Hua-Bin ; Yu,Zhi-Yong ; Xu,You-Kai
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	183 页码:112651
摘要	Eleven previously uncharacterized steroids, along with three analogs were isolated from Aglaia lawii leaves. Their structures were definitely characterized by the methods of NMR, MS, IR, ECD and X-ray crystallography study. Among these unreported compounds, 3-epi-dyscusin C, 3-epi-lansisterone E and (Z)-2 alpha-hydroxyaglawone were C-21 pregnane steroids incorporating a highly oxygenated ring A, while others were Delta(5)-3 beta-hydroxy-7-ketosteroids bearing different ring D and C-17 aliphatic chains. All isolates were evaluated for nitric oxide (NO) inhibitory activities. 3-Epi-dyscusin C, 3-epi-lansisterone E, (Z)-2 alpha-hydroxyaglawone and 17(20)E-dyscusin B showed significant anti-inflammatory activities with IC50 values of NO inhibition less than 10 mu M (in the range from 4.47 +/- 0.36 to 7.67 +/- 0.46 mu M).
关键词	Aglaia lawii Meliaceae Steroids Anti-inflammatory Nitric oxide PREGNANE STEROIDS MARINE STEROLS IDENTIFICATION SKELETON EPIMERS
DOI	10.1016/j.phytochem.2020.112651
WOS记录号	WOS:000631272700027
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73170
专题	中国科学院昆明植物研究所
作者单位	1.[Li, Jin-Feng 2.Ji, Kai-Long 3.Sun, Peng 4.Zheng, Xiao-Ling 5.Cao, Dong-Hua 6.Xiao, Chun-Fen 7.Zhang, Zong-Yi 8.Hu, Hua-Bin 9.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Mengla 666303, Yunnan, Peoples R China 10.[Cai, Qiang 11.Second Peoples Hosp Yunnan Prov, Dept Hepatobiliary Surg, 176 Qingnian Rd, Kunming 650021, Yunnan, Peoples R China 12.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650019, Yunnan, Peoples R China 13.[Xiao, Yi-Dian 14.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 15.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li,Jin-Feng,Ji,Kai-Long,Sun,Peng,et al. Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves[J]. PHYTOCHEMISTRY,2021,183:112651.
APA	Li,Jin-Feng.,Ji,Kai-Long.,Sun,Peng.,Cai,Qiang.,Zheng,Xiao-Ling.,...&Xu,You-Kai.(2021).Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves.PHYTOCHEMISTRY,183,112651.
MLA	Li,Jin-Feng,et al."Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves".PHYTOCHEMISTRY 183(2021):112651.