A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar

doi:10.1016/j.bmcl.2020.127682

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	A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar
	San,Thae Thae ; Wang,Yue-Hu ; Hu,Dong-Bao ; Yang,Jun ; Zhang,Dong-Dong ; Xia,Meng-Yuan ; Yang,Xue-Fei ; Yang,Yong-Ping
	2021
Source Publication	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
Volume	31 Pages:127682
Abstract	One new sesquineolignan, piperneolignan A (1), four new neolignans, piperneolignans B-E (2-5), and eight known compounds were isolated from the leaves of Piper betle (Piperaceae) collected from Myanmar. These new structures were determined by analysis of MS and NMR data, and the absolute configuration of piperneolignan A was elucidated by electronic circular dichroism (ECD) calculations. Piperneolignan A (1), piperneolignan B (2), hydroxychavicol (6), p-hydroxycinnamaldehyde (10), and diallylcatechol (13) possessed anti-inflammatory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells with IC50 values of 9.87, 45.94, 4.80, 26.40, and 40.45 mu M, respectively, compared with the positive control NG-monomethyl-L-arginine (L-NMMA, IC50 = 33.84 mu M). The two hydroxy groups in the structure of hydroxychavicol are essential for activity, and dimerization or trimerization of hydroxychavicol decreases activity.
Keyword	Myanmar Piper betle Piperaceae Neolignans Anti-inflammatory CHEMICAL-CONSTITUENTS IN-VITRO L. PHENYLPROPANOIDS IDENTIFICATION COMPONENTS ROOTS OIL
DOI	10.1016/j.bmcl.2020.127682
WOS ID	WOS:000602367900002
Citation statistics	Cited Times:9[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73148
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Nay Pyi Taw 05282, Myanmar 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	San,Thae Thae,Wang,Yue-Hu,Hu,Dong-Bao,et al. A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2021,31:127682.
APA	San,Thae Thae.,Wang,Yue-Hu.,Hu,Dong-Bao.,Yang,Jun.,Zhang,Dong-Dong.,...&Yang,Yong-Ping.(2021).A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,31,127682.
MLA	San,Thae Thae,et al."A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 31(2021):127682.

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