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| A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar | |
| San,Thae Thae; Wang,Yue-Hu; Hu,Dong-Bao; Yang,Jun; Zhang,Dong-Dong; Xia,Meng-Yuan; Yang,Xue-Fei; Yang,Yong-Ping | |
| 2021 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 0960-894X |
| 卷号 | 31页码:127682 |
| 摘要 | One new sesquineolignan, piperneolignan A (1), four new neolignans, piperneolignans B-E (2-5), and eight known compounds were isolated from the leaves of Piper betle (Piperaceae) collected from Myanmar. These new structures were determined by analysis of MS and NMR data, and the absolute configuration of piperneolignan A was elucidated by electronic circular dichroism (ECD) calculations. Piperneolignan A (1), piperneolignan B (2), hydroxychavicol (6), p-hydroxycinnamaldehyde (10), and diallylcatechol (13) possessed anti-inflammatory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells with IC50 values of 9.87, 45.94, 4.80, 26.40, and 40.45 mu M, respectively, compared with the positive control NG-monomethyl-L-arginine (L-NMMA, IC50 = 33.84 mu M). The two hydroxy groups in the structure of hydroxychavicol are essential for activity, and dimerization or trimerization of hydroxychavicol decreases activity. |
| 关键词 | Myanmar Piper betle Piperaceae Neolignans Anti-inflammatory CHEMICAL-CONSTITUENTS IN-VITRO L. PHENYLPROPANOIDS IDENTIFICATION COMPONENTS ROOTS OIL |
| DOI | 10.1016/j.bmcl.2020.127682 |
| WOS记录号 | WOS:000602367900002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/73148 |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Nay Pyi Taw 05282, Myanmar 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | San,Thae Thae,Wang,Yue-Hu,Hu,Dong-Bao,et al. A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2021,31:127682. |
| APA | San,Thae Thae.,Wang,Yue-Hu.,Hu,Dong-Bao.,Yang,Jun.,Zhang,Dong-Dong.,...&Yang,Yong-Ping.(2021).A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,31,127682. |
| MLA | San,Thae Thae,et al."A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 31(2021):127682. |
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| 94. A new sesquineol（1873KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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