Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans

doi:10.1016/j.bioorg.2020.104515

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	Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans
	Zhang,Yu; Bai,Xue ; Yuwen,Huan-Sha ; Guo,Ling-Li ; Liu,Jian-Wen ; Hao,Xiao-Jiang
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	107 页码:104515
摘要	Nineteen indole alkaloids including eleven new ones, taberdines A-K (1-11), were isolated from Tabernaemontana divaricata. Their structures were assigned by MS, NMR, single crystal X-ray diffractions, and ECD analyses. Alkaloid 1 is an aspidosperma-type monoterpenoid indole alkaloid and possesses a rearranged pyrrolidine moiety due to C-3 degradation, and 4 has a rare 1,3-oxazolidine moiety within iboga-type alkaloids. Alkaloids 2, 4, 6, and 11-19 combined with 5 mu g/mL fluconazole exhibited significant activity to reverse fluconazole resistance in Candida albicans strains while no one used alone showed any activities against the resistant strain.
关键词	Tabernaemontana divaricate Taberdines A-K Reversal of fluconazole resistance Candida albicans
DOI	10.1016/j.bioorg.2020.104515
WOS记录号	WOS:000618105400002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73046
专题	中国科学院昆明植物研究所
作者单位	1.[Zhang, Yu 2.Bai, Xue 3.Yuwen, Huan-Sha 4.Guo, Ling-Li 5.Liu, Jian-Wen 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang,Yu,Bai,Xue,Yuwen,Huan-Sha,et al. Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans[J]. BIOORGANIC CHEMISTRY,2021,107:104515.
APA	Zhang,Yu,Bai,Xue,Yuwen,Huan-Sha,Guo,Ling-Li,Liu,Jian-Wen,&Hao,Xiao-Jiang.(2021).Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans.BIOORGANIC CHEMISTRY,107,104515.
MLA	Zhang,Yu,et al."Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans".BIOORGANIC CHEMISTRY 107(2021):104515.

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