Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels

doi:10.1080/14786419.2020.1712387

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	Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels
	Xin,Ying ; Xu,Min ; Wang,Ya-Feng ; Zheng,Xiao-Hong ; Zhu,Hong-Tao ; Wang,Dong; Yang,Chong-Ren ; Zhang,Ying-Jun
	2021
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	35 期号:21 页码:3540-3547
摘要	A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
关键词	Phyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide TUSSILAGO-FARFARA FLOWER BUDS EXTRACTS PLANTS
DOI	10.1080/14786419.2020.1712387
WOS记录号	WOS:000509172800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73037
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China 3.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Xin,Ying,Xu,Min,Wang,Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2021,35(21):3540-3547.
APA	Xin,Ying.,Xu,Min.,Wang,Ya-Feng.,Zheng,Xiao-Hong.,Zhu,Hong-Tao.,...&Zhang,Ying-Jun.(2021).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,35(21),3540-3547.
MLA	Xin,Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH 35.21(2021):3540-3547.

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