Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata

doi:10.1039/d1qo00999k

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	Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata
	Wu,Xing-De ; Ding,Lin-Fen ; Chen,Bin ; Li,Xiao-Nian ; Peng,Li-Yan ; Zhao,Qin-Shi
	2021
发表期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
卷号	8 期号:20 页码:5777-5784
摘要	Cunlanceloic acid A (1), a symmetric terpenoid peroxide bearing an unprecedented dimeric labdane backbone linked through C-16/C-16 ' bonds, and cunlanceloic acids B-D (2-4), three asymmetric diterpenoid dimers with a new carbon skeleton linked through C12/C-13 ' and C-15/C-16 ' bonds between two labdane units, were isolated from the cones of Cunninghamia lanceolata. Their structures including absolute configurations were determined by extensive NMR spectroscopy, X-ray diffraction analysis, and chemical transformations. Compound 1 exhibited potent AChE inhibitory activity with an IC50 value of 6.14 +/- 0.66 mu M and compounds 2 and 3 showed remarkable cytotoxic activities against A-549 and SMMC-7721 cell lines with IC50 values of 5.90-9.21 mu M.
关键词	ASYMMETRIC-SYNTHESIS WOOD SESQUITERPENOIDS LEAVES ROOTS
DOI	10.1039/d1qo00999k
WOS记录号	WOS:000687330500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73014
专题	中国科学院昆明植物研究所
作者单位	1.[Wu, Xing-De 2.Ding, Lin-Fen 3.Chen, Bin 4.Li, Xiao-Nian 5.Peng, Li-Yan 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 8.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wu,Xing-De,Ding,Lin-Fen,Chen,Bin,et al. Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(20):5777-5784.
APA	Wu,Xing-De,Ding,Lin-Fen,Chen,Bin,Li,Xiao-Nian,Peng,Li-Yan,&Zhao,Qin-Shi.(2021).Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata.ORGANIC CHEMISTRY FRONTIERS,8(20),5777-5784.
MLA	Wu,Xing-De,et al."Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata".ORGANIC CHEMISTRY FRONTIERS 8.20(2021):5777-5784.

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