A cream of herbal mixture to improve melasma

doi:10.1111/jocd.12938

KIB OpenIR

	A cream of herbal mixture to improve melasma
	Zhang,Qiongyu; Tu,Ying; Gu,Hua; Sun,Dongjie; Wu,Wenjuan; Man,Mao-Qiang; Chen,Hongduo; Liu,Haiyang; Ma,Xiao; He,Li
通讯作者	He, Li(drheli2662@126.com)
	2019
发表期刊	JOURNAL OF COSMETIC DERMATOLOGY
ISSN	1473-2130
卷号	18 期号:6 页码:1721-1728
摘要	Background: Melasma is an acquired, common hyperpigmented disorder on the face. While many therapeutic approaches are available, their efficacy is moderate. Objective: To investigate the safety and efficacy of a cream containing herbal mixture for melasma. Methods: A total of 90 volunteers with melasma were enrolled in this randomized, double-blind, controlled clinical study, and they were randomly divided into three groups (A, B, and C). Patients in group A were treated with a cream containing herbal mixture, while groups B and C were treated with arbutin cream and placebo, respectively, twice daily for 12 weeks. Melasma area and severity index (MASI) score, melanin index (MI), erythema index (EI), changes in density of inflammatory cells, and adverse events were evaluated every 4 weeks. Results: Although MASI scores declined significantly in both groups A and B (P < 0.05), a greater reduction was seen in group A (13.00-9.82 = 3.18 for group A; 12.65-10.84 = 1.81 for group B). Moreover, the cream containing herbal mixture, but not arbutin cream and placebo, significantly reduced EI and density of inflammatory cells after 12-week treatment (P < 0.05). No adverse reactions were observed in either group A or group C. In group B, two subjects experienced mild erythema and itching, which disappeared after stop using the arbutin cream. Conclusion: The cream containing herbal mixture is safe and effective for melasma.
关键词	erythema index herbal mixture melanin index melasma melasma area and severity index score
DOI	10.1111/jocd.12938
收录类别	SCI
语种	英语
WOS记录号	WOS:000518545000024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/71118
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang,Qiongyu,Tu,Ying,Gu,Hua,et al. A cream of herbal mixture to improve melasma[J]. JOURNAL OF COSMETIC DERMATOLOGY,2019,18(6):1721-1728.
APA	Zhang,Qiongyu.,Tu,Ying.,Gu,Hua.,Sun,Dongjie.,Wu,Wenjuan.,...&He,Li.(2019).A cream of herbal mixture to improve melasma.JOURNAL OF COSMETIC DERMATOLOGY,18(6),1721-1728.
MLA	Zhang,Qiongyu,et al."A cream of herbal mixture to improve melasma".JOURNAL OF COSMETIC DERMATOLOGY 18.6(2019):1721-1728.

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