Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim

doi:10.1016/j.phytochem.2019.112125

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	Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim
	Li,Dan; Liu,Hui; Ni,Wei; Xiao,Wei-Lie; He,Li; Guo,Zhen-Yu; Qin,Xu-Jie; Liu,Hai-Yang
	2019
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	168 页码:UNSP 112125
摘要	Nine undescribed polyacetylated 18-norspirostanol saponins, trilliumosides A-J, were obtained after a guidance based on a molecular networking strategy from the rhizomes of Trillium tschonoskii. Their structures were established by analysis of comprehensive spectroscopic data and chemical methods after their isolation in pure form. All isolated saponins were evaluated for their cytotoxicities against five selected human cancer cell lines (Huh7,A549,MCF-7,HepG2, and MOLT-4) and anti-inflammatory effects on a lipopolysaccharide (LPS) stimulated NO production model in RAW264.7 macrophages. Trilliumoside D showed significant cytotoxicity against MOLT-4 cell lines with an IC50 value of 1.0 +/- 0.1 mu M, whereas trilliumosides H and I displayed remarkable anti-inflammatory effects on NO production with inhibitory rates of 56.3 +/- 1.5 and 56.2 +/- 2.246 at the concentration of 1.0 mu M, respectively.
DOI	10.1016/j.phytochem.2019.112125
收录类别	SCI
WOS记录号	WOS:000496894000009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/71057
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li,Dan,Liu,Hui,Ni,Wei,et al. Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim[J]. PHYTOCHEMISTRY,2019,168:UNSP 112125.
APA	Li,Dan.,Liu,Hui.,Ni,Wei.,Xiao,Wei-Lie.,He,Li.,...&Liu,Hai-Yang.(2019).Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim.PHYTOCHEMISTRY,168,UNSP 112125.
MLA	Li,Dan,et al."Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim".PHYTOCHEMISTRY 168(2019):UNSP 112125.

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