Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine
Yao, Jian-Neng1,2; Liang, Xiao1; Wei, Kun1; Yang, Yu-Rong1
Corresponding AuthorYang, Yu-Rong(yangyurong@mail.kib.ac.cn)
2019-10-18
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:20Pages:8485-8487
AbstractA catalytic, enantioselective formal synthesis of monoterpene indole alkaloid (-)-alstoscholarine is described. The synthesis employs an Ir-amine dual catalyzed asymmetric allylation of aldehyde 8 with 3-indolyl vinyl carbinol derivative 7 to furnish chiral aldehyde 6 as a key asymmetric step. Other key reactions include the construction of the 2-ketopyrrole moiety by Nicolaou's method and Tf2O promoted Pictet Spengler cyclization to access Zhu's intermediate 3.
DOI10.1021/acs.orglett.9b03319
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000492114600070
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70974
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorYang, Yu-Rong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yao, Jian-Neng,Liang, Xiao,Wei, Kun,et al. Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine[J]. ORGANIC LETTERS,2019,21(20):8485-8487.
APA Yao, Jian-Neng,Liang, Xiao,Wei, Kun,&Yang, Yu-Rong.(2019).Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine.ORGANIC LETTERS,21(20),8485-8487.
MLA Yao, Jian-Neng,et al."Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine".ORGANIC LETTERS 21.20(2019):8485-8487.
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